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dc.contributor.author
Grosso, Tomás Martín  
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Alcamí, José  
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Arribas, José R.  
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Martín, Marta  
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Sereti, Irini  
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Tarr, Philip  
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Cahn, Pedro  
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Clotet, Bonaventura  
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Sued, Omar Gustavo  
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Negredo, Eugenia  
dc.date.available
2023-06-23T18:45:05Z  
dc.date.issued
2022-06  
dc.identifier.citation
Grosso, Tomás Martín; Alcamí, José; Arribas, José R.; Martín, Marta; Sereti, Irini; et al.; HIV and aging, biological mechanisms, and therapies: What do we know?; Permanyer; Aids Reviews; 24; 2; 6-2022; 79-86  
dc.identifier.issn
1139-6121  
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http://hdl.handle.net/11336/201358  
dc.description.abstract
Aging, a time-dependent loss of physiological function, and its drivers are turning into a significant topic of research as the population’s mean age increases. Epigenetic alterations, telomere shortening or dysfunction, mitogenic stress, oxidative stress, or accumulation of DNA damage can drive the cell to senescence: a permanent cell cycle arrest sometimes associated with a secretory phenotype and inflammatory consequences in the surrounding tissue. The amount of senescent cells grows over time in older organisms and may induce tissue inflammation and threaten overall tissue homeostasis, favoring aging. Senolytic and senomorphic therapeutics are an emerging approach to eliminate senescent cells or to block their secretory phenotypes respectively. Given that people living with HIV suffer non-AIDS comorbidities in a higher prevalence than the general population, aging is accentuated among them. Inflammation biomarkers may be helpful to assess prognosis or act as surrogate endpoints for studies of strategies focused on reversal of HIV-associated accelerated aging. This review summarizes the latest findings in aging and its major drivers, under the light of HIV infection. Since the number of older PLWH is currently rising, it will be of great importance to address and treat their age-related conditions, as well as to better decipher their biological mechanisms.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Permanyer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AGING  
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CELLULAR SENESCENCE  
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GENOMIC INSTABILITY  
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HIV INFECTION  
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SENOLYTICS  
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TELOMERES  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Geriatría y Gerontología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
HIV and aging, biological mechanisms, and therapies: What do we know?  
dc.type
info:eu-repo/semantics/article  
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info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-06-21T16:37:13Z  
dc.identifier.eissn
1698-6997  
dc.journal.volume
24  
dc.journal.number
2  
dc.journal.pagination
79-86  
dc.journal.pais
España  
dc.journal.ciudad
Mallorca  
dc.description.fil
Fil: Grosso, Tomás Martín. Universidad Nacional de Lujan. Departamento de Cs.basicas. Laboratorio de Inmunologia.; Argentina. Fundación Huésped; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Alcamí, José. Hospital Clínic de Barcelona; Argentina. Instituto de Salud Carlos III; España  
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Fil: Arribas, José R.. Instituto de Investigacion del Hospital de la Paz.; España  
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Fil: Martín, Marta. Universitat Autònoma de Barcelona; España  
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Fil: Sereti, Irini. National Institute Of Allegry & Infectious Diseases (niaid) ; National Institutes Of Health;  
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Fil: Tarr, Philip. Universidad de Basilea; Suiza  
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Fil: Cahn, Pedro. Fundación Huésped; Argentina  
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Fil: Clotet, Bonaventura. Universitat Autònoma de Barcelona; España. Universitat Central Catalunya; España  
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Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina  
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Fil: Negredo, Eugenia. Universitat Autònoma de Barcelona; España. Universitat Central Catalunya; España  
dc.journal.title
Aids Reviews  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.aidsreviews.com/resumen.php?id=1606  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.24875/AIDSRev.21000085