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dc.contributor.author
Grosso, Tomás Martín
dc.contributor.author
Alcamí, José
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Arribas, José R.
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Martín, Marta
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Sereti, Irini
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Tarr, Philip
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Cahn, Pedro
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Clotet, Bonaventura
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Sued, Omar Gustavo
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Negredo, Eugenia
dc.date.available
2023-06-23T18:45:05Z
dc.date.issued
2022-06
dc.identifier.citation
Grosso, Tomás Martín; Alcamí, José; Arribas, José R.; Martín, Marta; Sereti, Irini; et al.; HIV and aging, biological mechanisms, and therapies: What do we know?; Permanyer; Aids Reviews; 24; 2; 6-2022; 79-86
dc.identifier.issn
1139-6121
dc.identifier.uri
http://hdl.handle.net/11336/201358
dc.description.abstract
Aging, a time-dependent loss of physiological function, and its drivers are turning into a significant topic of research as the population’s mean age increases. Epigenetic alterations, telomere shortening or dysfunction, mitogenic stress, oxidative stress, or accumulation of DNA damage can drive the cell to senescence: a permanent cell cycle arrest sometimes associated with a secretory phenotype and inflammatory consequences in the surrounding tissue. The amount of senescent cells grows over time in older organisms and may induce tissue inflammation and threaten overall tissue homeostasis, favoring aging. Senolytic and senomorphic therapeutics are an emerging approach to eliminate senescent cells or to block their secretory phenotypes respectively. Given that people living with HIV suffer non-AIDS comorbidities in a higher prevalence than the general population, aging is accentuated among them. Inflammation biomarkers may be helpful to assess prognosis or act as surrogate endpoints for studies of strategies focused on reversal of HIV-associated accelerated aging. This review summarizes the latest findings in aging and its major drivers, under the light of HIV infection. Since the number of older PLWH is currently rising, it will be of great importance to address and treat their age-related conditions, as well as to better decipher their biological mechanisms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Permanyer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGING
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CELLULAR SENESCENCE
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GENOMIC INSTABILITY
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HIV INFECTION
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SENOLYTICS
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TELOMERES
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Geriatría y Gerontología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
HIV and aging, biological mechanisms, and therapies: What do we know?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-21T16:37:13Z
dc.identifier.eissn
1698-6997
dc.journal.volume
24
dc.journal.number
2
dc.journal.pagination
79-86
dc.journal.pais
España
dc.journal.ciudad
Mallorca
dc.description.fil
Fil: Grosso, Tomás Martín. Universidad Nacional de Lujan. Departamento de Cs.basicas. Laboratorio de Inmunologia.; Argentina. Fundación Huésped; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Alcamí, José. Hospital Clínic de Barcelona; Argentina. Instituto de Salud Carlos III; España
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Fil: Arribas, José R.. Instituto de Investigacion del Hospital de la Paz.; España
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Fil: Martín, Marta. Universitat Autònoma de Barcelona; España
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Fil: Sereti, Irini. National Institute Of Allegry & Infectious Diseases (niaid) ; National Institutes Of Health;
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Fil: Tarr, Philip. Universidad de Basilea; Suiza
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Fil: Cahn, Pedro. Fundación Huésped; Argentina
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Fil: Clotet, Bonaventura. Universitat Autònoma de Barcelona; España. Universitat Central Catalunya; España
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Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina
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Fil: Negredo, Eugenia. Universitat Autònoma de Barcelona; España. Universitat Central Catalunya; España
dc.journal.title
Aids Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.aidsreviews.com/resumen.php?id=1606
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.24875/AIDSRev.21000085
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