Differentiation of 3T3-L1 preadipocytes into beige adipocytes contribute to breast cancer progression

Abstract

Crosstalk between breast cancer cells and adipose tissue in the mammary microenvironment plays a key role in the regulation of tumor behavior. We previously demonstrated morphologic and metabolic changes in adipocytes indirectly cocultured with breast cancer cells, suggesting a first step towards browning of adipose tissue, which is an important contribution to the hypermetabolic state of breast cancer. Thus, the aim of study was to obtain insight into the effect of epithelial cell-beige adipocyte communication on tumor progression.