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dc.contributor.author
Lincoln, Richard
dc.contributor.author
Durantini, Andres Matias
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Green, Lana E.
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Martinez, Sol Romina
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Knox, R.
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Becerra, María Cecilia
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Cosa, Gonzalo
dc.date.available
2017-07-11T16:30:11Z
dc.date.issued
2016-12
dc.identifier.citation
Lincoln, Richard; Durantini, Andres Matias; Green, Lana E.; Martinez, Sol Romina; Knox, R.; et al.; meso-Acetoxymethyl BODIPY dyes for photodynamic therapy: improved photostability of singlet oxygen photosensitizers; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 16; 2; 12-2016; 178-184
dc.identifier.issn
1474-905X
dc.identifier.uri
http://hdl.handle.net/11336/20120
dc.description.abstract
We report two BODIPY based photosensitizers (Br2BOAc and I2BOAc) featuring an acetoxymethyl substituent at the meso-position. These photosensitizers show improved photostability against singlet oxygen, when compared to a BODIPY photosensitizer lacking the acetoxymethyl group. Both compounds were evaluated for photodynamic therapy against HeLa cells and photodynamic inactivation against E. coli bacteria. We show that the compounds readily embed in the lipid membranes of HeLa cervical cancer cells and efficiently induced light-dependent apoptosis at nanomolar concentration. Also, both compounds showed a substantial degree of photoinactivation of E. coli bacteria when used at low micromolar concentrations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bodipy
dc.subject
Pdt
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Bacteria
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Imaging
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Hella Cells
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
meso-Acetoxymethyl BODIPY dyes for photodynamic therapy: improved photostability of singlet oxygen photosensitizers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-29T13:55:11Z
dc.identifier.eissn
1474-9092
dc.journal.volume
16
dc.journal.number
2
dc.journal.pagination
178-184
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Lincoln, Richard. McGill University. Department of Chemistry and Center for Self Assembled Chemical Structures; Canadá
dc.description.fil
Fil: Durantini, Andres Matias. McGill University. Department of Chemistry and Center for Self Assembled Chemical Structures; Canadá
dc.description.fil
Fil: Green, Lana E.. McGill University; Canadá
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Fil: Martinez, Sol Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Knox, R.. McGill University. Department of Chemistry and Center for Self Assembled Chemical Structures; Canadá
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Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Cosa, Gonzalo. McGill University. Department of Chemistry and Center for Self Assembled Chemical Structures; Canadá
dc.journal.title
Photochemical and Photobiological Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1039/C6PP00166A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2017/pp/c6pp00166a/unauth#!divAbstract
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