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dc.contributor.author
Bouzat, Cecilia Beatriz
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dc.contributor.other
Celej, Maria Soledad
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dc.contributor.other
Acierno, Juan Pablo
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dc.date.available
2023-06-21T18:01:37Z
dc.date.issued
2018
dc.identifier.citation
Nicotinic receptors as therapeutic drug targets: Molecular bases of function, dysfunction and drug modulation; XLVII Reunión Anual de la Sociedad Argentina de Biofísica; La Plata; Argentina; 2018; 26-26
dc.identifier.isbn
978-987-27591-6-2
dc.identifier.uri
http://hdl.handle.net/11336/201047
dc.description.abstract
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels widely expressed in neuronal and non-neuronal cells in both vertebrates and invertebrates. In humans, dysfunction of nAChRs is associated with neurological, muscular and immune disorders. The nAChR operates as a molecular machine that transduces the binding of ACh into an electrical signal. Its molecular design has been tuned to function as a near perfect on-off switch that responds to ACh with the efficiency and speed required for proper cell function. We have combined mutagenesis, patch-clamp recordings, single-channel kinetic analysis and in silico studies to unravel the molecular mechanisms and structures underlying nAChR activation and modulation as well as to identify compounds with potential therapeutic use. For the muscle nAChR, a key protagonist in muscle contraction, we have postulated mechanisms that describe its activation and modulation, deciphered how mutations lead to congenital myasthenic syndromes, and explored worm receptors as antiparasitic drug targets. We have also focused on α7 nAChR, which is the homomeric member of the family and is involved in cognition, attention, memory and inflammation. We have revealed unique aspects of α7 activation as well as mechanisms and sites of action of positive allosteric modulators, which are promising therapeutic tools for schizophrenia and Alzheimer’s disease. We have also identified the molecular function of novel heteromeric nAChRs containing the α7 subunit. Overall, our studies have allowed an integrated description of the nAChR, providing information of its molecular function in health and disease states and guiding rational therapy
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Biofísica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NICOTINIC RECEPTORS
dc.subject
THERAPEUTIC DRUG TARGETS
dc.subject
DRUG MODULATION
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Nicotinic receptors as therapeutic drug targets: Molecular bases of function, dysfunction and drug modulation
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2023-06-01T10:18:05Z
dc.journal.pagination
26-26
dc.journal.pais
Argentina
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dc.journal.ciudad
La Plata
dc.description.fil
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://biofisica.org.ar/reuniones-cientificas/reunionsab-previas/
dc.conicet.rol
Autor
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dc.coverage
Nacional
dc.type.subtype
Conferencia
dc.description.nombreEvento
XLVII Reunión Anual de la Sociedad Argentina de Biofísica
dc.date.evento
2018-12-05
dc.description.ciudadEvento
La Plata
dc.description.paisEvento
Argentina
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dc.type.publicacion
Book
dc.description.institucionOrganizadora
Sociedad Argentina de Biofísica
dc.source.libro
XLVII Reunión Anual de la Sociedad Argentina de Biofísica: libro de resúmenes
dc.date.eventoHasta
2018-12-07
dc.type
Conferencia
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