Artículo
Photoactive Red Fluorescent SiO2Nanoparticles Based on Controlled Methylene Blue Aggregation in Reverse Microemulsions
Toum Terrones, Yamili
; Torresan, Maria Fernanda
; Mirenda, Martin
; Rodriguez, Hernan Bernardo
; Wolosiuk, Alejandro
Fecha de publicación:
06/2022
Editorial:
American Chemical Society
Revista:
Langmuir
ISSN:
0743-7463
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We present a reverse microemulsion synthesis procedure for incorporating methylene blue (MB), a known FDA-approved type-II red-absorbing photosensitizer and 1O2generator, into the matrix of hydrophobic-core/hydrophilic-shell SiO2nanoparticles. Different synthesis conditions were explored with the aim of controlling the entrapped-dye aggregation at high dye loadings in the hydrophobic protective core; minimizing dye aggregation ensured highly efficient photoactive nanoentities for 1O2production. Monitoring the synthesis in real time using UV-vis absorption allowed tracking of the dye aggregation process. In particular, silica nanoparticles (MB@SiO2NPs) of ∼50 nm diameter size with a high local entrapped-MB concentration (∼10-2M, 1000 MB molecules per NP) and a moderate proportion of dye aggregation were obtained. The as-prepared MB@SiO2NPs showed a high singlet oxygen photogeneration efficiency (φΔ= 0.30 ± 0.05), and they can be also considered as red fluorescent probes (φF∼0.02, λmax∼650 nm). The distinctive photophysical and photochemical characteristics of the synthesized NPs reveal that the reverse microemulsion synthesis procedure offers an interesting strategy for the development of complex theranostic nano-objects for photodynamic therapy.
Palabras clave:
Absorption
,
Dyes and pigments
,
Emulsions
,
Monomers
,
Nanoparticles
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Identificadores
Colecciones
Articulos (UE-INN - NODO CONSTITUYENTES)
Articulos de UNIDAD EJECUTORA INSTITUTO DE NANOCIENCIA Y NANOTECNOLOGIA - NODO CONSTITUYENTES
Articulos de UNIDAD EJECUTORA INSTITUTO DE NANOCIENCIA Y NANOTECNOLOGIA - NODO CONSTITUYENTES
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Toum Terrones, Yamili; Torresan, Maria Fernanda; Mirenda, Martin; Rodriguez, Hernan Bernardo; Wolosiuk, Alejandro; Photoactive Red Fluorescent SiO2Nanoparticles Based on Controlled Methylene Blue Aggregation in Reverse Microemulsions; American Chemical Society; Langmuir; 38; 22; 6-2022; 6786-6797
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