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dc.contributor.author
Reis, Pedro B. P. S.
dc.contributor.author
Barletta Roldan, Patricio German
dc.contributor.author
Gagliardi, Lucas
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Fortuna, Sara
dc.contributor.author
Soler, Miguel A.
dc.contributor.author
Rocchia, Walter
dc.date.available
2023-06-21T15:31:26Z
dc.date.issued
2022-07
dc.identifier.citation
Reis, Pedro B. P. S.; Barletta Roldan, Patricio German; Gagliardi, Lucas; Fortuna, Sara; Soler, Miguel A.; et al.; Antibody-Antigen Binding Interface Analysis in the Big Data Era; Frontiers Media; Frontiers in Molecular Biosciences; 9; 7-2022; 1-17
dc.identifier.issn
2296-889X
dc.identifier.uri
http://hdl.handle.net/11336/200993
dc.description.abstract
Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBODY-ANTIGEN COMPLEX
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COMPLEMENTARITY-DETERMINING REGION (CDR)
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EPITOPE ANALYSIS
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PARATOPE ANALYSIS
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STRUCTURE ANALYSIS AND CHARACTERIZATION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antibody-Antigen Binding Interface Analysis in the Big Data Era
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-21T10:47:05Z
dc.journal.volume
9
dc.journal.pagination
1-17
dc.journal.pais
Suiza
dc.description.fil
Fil: Reis, Pedro B. P. S.. Istituto Italiano Di Technologie; Italia. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Barletta Roldan, Patricio German. The Abdus Salam; Italia. The Abdus Salam. International Centre for Theoretical Physics; Italia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gagliardi, Lucas. Istituto Italiano Di Technologie; Italia
dc.description.fil
Fil: Fortuna, Sara. Istituto Italiano Di Technologie; Italia
dc.description.fil
Fil: Soler, Miguel A.. Istituto Italiano Di Technologie; Italia
dc.description.fil
Fil: Rocchia, Walter. Istituto Italiano Di Technologie; Italia
dc.journal.title
Frontiers in Molecular Biosciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fmolb.2022.945808
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