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dc.contributor.author
Georges, Claire
dc.contributor.author
Perez Lloret, Santiago
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dc.contributor.author
Ory Magne, Fabienne
dc.contributor.author
Fabbri, Margherita
dc.contributor.author
Foubert Samier, Alexandra
dc.contributor.author
Meissner, Wassilios G.
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dc.contributor.author
Rascol, Olivier
dc.contributor.author
Pavy Le Traon, Anne
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dc.date.available
2023-06-16T17:09:22Z
dc.date.issued
2022-10
dc.identifier.citation
Georges, Claire; Perez Lloret, Santiago; Ory Magne, Fabienne; Fabbri, Margherita; Foubert Samier, Alexandra; et al.; Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy; Elsevier; Parkinsonism & Related Disorders; 103; 10-2022; 56-59
dc.identifier.issn
1353-8020
dc.identifier.uri
http://hdl.handle.net/11336/200864
dc.description.abstract
Background: Multiple System Atrophy (MSA) is a rare neurodegenerative disease with pronounced autonomic failure (AF). Severe cardiovascular AF is associated with poor prognosis. Since sweating dysfunction is less well known, we investigated the interest of a quick and non-invasive assessment of sweating using electrochemical skin conductance (ESC) as a marker for AF in MSA. Methods: 138 MSA patients of the French Reference center for MSA with an annual follow-up including the Unified MSA Rating Scale (UMSARS), COMPASS (autonomic symptoms) and measurements of foot and hand ESC (Sudoscan®) participated to this study (age 65 ± 8 years, 66% probable MSA, 72% AMS-P). Statistical analysis included: (i) correlations between ESC and MSA type, age, disease duration, severity, blood pressure (BP), COMPASS, (ii) comparisons between groups with normal or abnormal ESC, and (iii) multivariate analysis by logistic regression. Relationships between severity progression during follow-up with ESC and other variables were modeled by Generalized Estimating Equation. Results: Hands and feet ESCs were abnormal in 81/138 (59%) and 93/138 (67%) cases, respectively. Abnormal ESCs were significantly correlated to disease severity and several features of AF. ESCs worsening over time was more pronounced than other autonomic features such as orthostatic hypotension. Abnormal ESCs at baseline were significantly associated with a higher progression of UMSARS's score during follow-up. Conclusion: Sweating dysfunction assessed by ESC is frequent in MSA and is significantly related to disease severity and AF. The gradual decrease in ESC with disease duration could be useful as a quantitative marker of autonomic dysfunction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTONOMIC FAILURE
dc.subject
MULTIPLE SYSTEM ATROPHY
dc.subject
ORTHOSTATIC HYPOTENSION
dc.subject
SWEATING ASSESSMENT
dc.subject.classification
Neurología Clínica
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Alterations in electrochemical skin conductance as a marker of autonomic dysfunction in multiple system atrophy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-14T10:57:00Z
dc.journal.volume
103
dc.journal.pagination
56-59
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Georges, Claire. No especifíca;
dc.description.fil
Fil: Perez Lloret, Santiago. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ory Magne, Fabienne. No especifíca;
dc.description.fil
Fil: Fabbri, Margherita. No especifíca;
dc.description.fil
Fil: Foubert Samier, Alexandra. Universite de Bordeaux; Francia
dc.description.fil
Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia
dc.description.fil
Fil: Rascol, Olivier. Inserm; Francia
dc.description.fil
Fil: Pavy Le Traon, Anne. No especifíca;
dc.journal.title
Parkinsonism & Related Disorders
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.parkreldis.2022.08.026
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