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dc.contributor.author
Pirola, Carlos Jose  
dc.contributor.author
Sookoian, Silvia Cristina  
dc.date.available
2023-06-13T18:02:52Z  
dc.date.issued
2022-03  
dc.identifier.citation
Pirola, Carlos Jose; Sookoian, Silvia Cristina; MicroRNAs as messengers of liver diseases: has the message finally been decrypted?; Journal of the Serbian Chemical Society; Clinical Science; 136; 5; 3-2022; 323-328  
dc.identifier.issn
0143-5221  
dc.identifier.uri
http://hdl.handle.net/11336/200494  
dc.description.abstract
MicroRNAs (miRNAs), which are regarded as crucial regulators of gene expression and diverse aspects of cell biology, can be present in various body fluids as highly stable molecules. It is also known that miRNAs exert tissue-specific regulation of gene transcription. Large amount of clinical and experimental evidence provided the rationale for raising the intriguing question of whether miRNAs can mediate cell–cell communication. For those reasons, miRNAs have been considered as the ‘Holy Grail’ of biomarkers allowing non-invasive diagnostic screening and early detection of a variety of diseases, including solid and non-solid cancers. In a study published in Clin. Sci. (Lond.) (2011) 120(5):183–193 (https://doi.org/10.1042/CS20100297), Gui et al. investigated the hypothesis that circulating miRNAs could be used to identify patients with liver pathologies. Specifically, the authors profiled circulating miRNAs in patients with hepatocellular carcinoma (HCC), liver cirrhosis (LC), and healthy controls and found that serum miR-885-5p levels were significantly higher in samples of patients with HCC (6.5-fold increase) and LC (8.8-fold increase). In this commentary, we highlight biological aspects associated with mir-122-the ‘liver-specific’ miRNA, which has been associated with a diverse range of liver pathologies. In addition, we discuss the relevance of mir-885-5p as potential biomarker for detecting human cancers. Finally, we provide some clues about how presumably unrelated miRNAs such as miR-122 and miR-885-5p may act in similar biological processes (BPs), making the miRNA regulatory networks more complex than anticipated.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Journal of the Serbian Chemical Society  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
MIRNAS  
dc.subject
LIVER DISEASES  
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BIOMARKERS  
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HEPATOCELLULAR CARCINOMA  
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Genética Humana  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Bioquímica y Biología Molecular  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Gastroenterología y Hepatología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
MicroRNAs as messengers of liver diseases: has the message finally been decrypted?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-06-12T13:50:43Z  
dc.journal.volume
136  
dc.journal.number
5  
dc.journal.pagination
323-328  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina  
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina  
dc.journal.title
Clinical Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/clinsci/article/136/5/323/230968/MicroRNAs-as-messengers-of-liver-diseases-has-the  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1042/CS20211177