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dc.contributor.author
Vera, Domingo Mariano Adolfo
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dc.contributor.author
Haynes, Mark H.
dc.contributor.author
Ball, Anthony R.
dc.contributor.author
Dai, Tianhong
dc.contributor.author
Astrakas, Christos
dc.contributor.author
Kelso, Michael J.
dc.contributor.author
Hamblin, Michael R.
dc.contributor.author
Tegos, George P.
dc.date.available
2023-06-06T11:18:43Z
dc.date.issued
2012-05
dc.identifier.citation
Vera, Domingo Mariano Adolfo; Haynes, Mark H.; Ball, Anthony R.; Dai, Tianhong; Astrakas, Christos; et al.; Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes; Wiley Blackwell Publishing, Inc; Photochemistry and Photobiology; 88; 3; 5-2012; 499-511
dc.identifier.issn
0031-8655
dc.identifier.uri
http://hdl.handle.net/11336/199672
dc.description.abstract
Conventional antimicrobial strategies have become increasinglyineffective due to the emergence of multidrug resistance amongpathogenic microorganisms. The need to overcome these deficiencieshas triggered the exploration of alternative treatmentsand unconventional approaches towards controlling microbialinfections. Photodynamic therapy (PDT) was originally establishedas an anticancer modality and is currently used in thetreatment of age-related macular degeneration. The concept ofphotodynamic inactivation requires cell exposure to light energy,typically wavelengths in the visible region that causes theexcitation of photosensitizer molecules either exogenous orendogenous, which results in the production of reactive oxygenspecies (ROS). ROS produce cell inactivation and death throughmodification of intracellular components. The versatile characteristicsof PDT prompted its investigation as an anti-infectivediscovery platform. Advances in understanding of microbialphysiology have shed light on a series of pathways, andphenotypes that serve as putative targets for antimicrobial drugdiscovery. Investigations of these phenotypic elements in concertwith PDT have been reported focused on multidrug effluxsystems, biofilms, virulence and pathogenesis determinants.In many instances the results are promising but only preliminaryand require further investigation. This review discusses thedifferent antimicrobial PDT strategies and highlights the needfor highly informative and comprehensive discovery approaches.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antimicrobial photodynmic therapy
dc.subject
excited triplet
dc.subject
Multidrug Resistance
dc.subject
ROS
dc.subject
MDR inhibitors
dc.subject
resistant strains
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-05T11:58:41Z
dc.journal.volume
88
dc.journal.number
3
dc.journal.pagination
499-511
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Vera, Domingo Mariano Adolfo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina
dc.description.fil
Fil: Haynes, Mark H.. University of New Mexico; Estados Unidos
dc.description.fil
Fil: Ball, Anthony R.. No especifíca;
dc.description.fil
Fil: Dai, Tianhong. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Astrakas, Christos. Democritus University of Thrace Medical School; Grecia
dc.description.fil
Fil: Kelso, Michael J.. University Of Wollongong; Australia
dc.description.fil
Fil: Hamblin, Michael R.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Tegos, George P.. University Of New Mexico. School Of Medicine; Estados Unidos. Harvard Medical School; Estados Unidos. University of New Mexico; Estados Unidos
dc.journal.title
Photochemistry and Photobiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2012.01087.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1751-1097.2012.01087.x
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