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dc.contributor.author
Martijena, Irene Delia
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dc.contributor.author
Molina, Victor Alejandro
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dc.date.available
2023-06-01T15:16:17Z
dc.date.issued
2012-04
dc.identifier.citation
Martijena, Irene Delia; Molina, Victor Alejandro; The influence of stress on fear memory processes; Associação Brasileira de Divulgação Científica; Brazilian Journal of Medical and Biological Research; 45; 4; 4-2012; 308-313
dc.identifier.issn
0100-879X
dc.identifier.uri
http://hdl.handle.net/11336/199297
dc.description.abstract
It is well recognized that stressful experiences promote robust emotional memories, which are well remembered. The amygdaloid complex, principally the basolateral complex (BLA), plays a pivotal role in fear memory and in the modulation of stress-induced emotional responses. A large number of reports have revealed that GABAergic interneurons provide a powerful inhibitory control of the activity of projecting glutamatergic neurons in the BLA. Indeed, a reduced GABAergic control in the BLA is essential for the stress-induced influence on the emergence of associative fear memory and on the generation of long-term potentiation (LTP) in BLA neurons. The extracellular signal-regulated kinase (ERK) subfamily of the mitogen-activated protein kinase (MAPK) signaling pathway in the BLA plays a central role in the consolidation process and synaptic plasticity. In support of the view that stress facilitates long-term fear memory, stressed animals exhibited a phospho-ERK2 (pERK2) increase in the BLA, suggesting the involvement of this mechanism in the promoting influence of threatening stimuli on the consolidation fear memory. Moreover, the occurrence of reactivation-induced lability is prevented when fear memory is encoded under intense stressful conditions since the memory trace remains immune to disruption after recall in previously stressed animals. Thus, the underlying mechanism in retrieval-induced instability seems not to be functional in memories formed under stress. All these findings are indicative that stress influences both the consolidation and reconsolidation fear memory processes. Thus, it seems reasonable to propose that the emotional state generated by an environmental challenge critically modulates the formation and maintenance of long-term fear memory.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Associação Brasileira de Divulgação Científica
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMYGDALA
dc.subject
FEAR
dc.subject
GABA
dc.subject
MEMORY
dc.subject
STRESS
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The influence of stress on fear memory processes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-30T11:51:37Z
dc.identifier.eissn
1414-431X
dc.journal.volume
45
dc.journal.number
4
dc.journal.pagination
308-313
dc.journal.pais
Brasil
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dc.journal.ciudad
San Pablo
dc.description.fil
Fil: Martijena, Irene Delia. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Molina, Victor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
dc.journal.title
Brazilian Journal of Medical and Biological Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S0100-879X2012007500045
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/bjmbr/a/5sjq8Yrm6P8ZH346kmsG7Sn/?lang=en
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