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dc.contributor.author
Woltmann, Eva
dc.contributor.author
Meyer, Hans
dc.contributor.author
Weigel, Diana
dc.contributor.author
Pritzke, Heinz
dc.contributor.author
Posch, Tjorben N.
dc.contributor.author
Kler, Pablo Alejandro
dc.contributor.author
Schürmann, Klaus
dc.contributor.author
Roscher, Jörg
dc.contributor.author
Huhn, Carolin
dc.date.available
2017-07-07T20:34:47Z
dc.date.issued
2014-10
dc.identifier.citation
Woltmann, Eva; Meyer, Hans; Weigel, Diana; Pritzke, Heinz; Posch, Tjorben N.; et al.; Applicability of UV-laser-induced solid-state fluorescence spectroscopy for the characterization solid dosage forms; Springer; Analytical and Bioanalytical Chemistry; 406; 25; 10-2014; 6347-6362
dc.identifier.issn
1618-2642
dc.identifier.uri
http://hdl.handle.net/11336/19919
dc.description.abstract
High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization of an instrumental setup for rapid and non-invasive characterization of tablets by laser-induced fluorescence spectroscopy (with a UV-laser (λ ex = 266 nm) as excitation source) in reflection geometry. The setup was first validated with regard to repeatability, bleaching phenomena, and sensitivity. The effect on the spectra by the physical and chemical properties of the samples, e.g. their hardness, homogeneity, chemical composition, and granule grain size of the uncompressed material, using a series of tablets, manufactured in accordance with design of experiments, was investigated. Investigation of tablets with regard to homogeneity, especially, is extremely important in pharmaceutical production processes. We demonstrate that multiplicative scatter correction is an appropriate tool for data preprocessing of fluorescence spectra. Tablets with different physical and chemical characteristics can be discriminated well from their fluorescence spectra by subjecting the results to principal component analysis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tablet Analysis
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Solid-State Fluorescence Spectroscopy
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Grain Size
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Photobleaching
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Scattering Effects
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Homogeneity
dc.subject.classification
Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Applicability of UV-laser-induced solid-state fluorescence spectroscopy for the characterization solid dosage forms
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-03T19:51:41Z
dc.journal.volume
406
dc.journal.number
25
dc.journal.pagination
6347-6362
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Woltmann, Eva. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil
Fil: Meyer, Hans. J&M Analytik AG; Alemania
dc.description.fil
Fil: Weigel, Diana. Federal Criminal Police Office, Forensic Science Institute, KT 34 – Toxicology; Alemania
dc.description.fil
Fil: Pritzke, Heinz. Glatt Systemtechnik GmbH; Alemania
dc.description.fil
Fil: Posch, Tjorben N.. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil
Fil: Kler, Pablo Alejandro. Universität Tübingen. Institute of Physical and Theoretical Chemistry, Eberhard Karls ; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones En Metodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones En Metodos Computacionales; Argentina. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil
Fil: Schürmann, Klaus. LabCognition Analytical Software GmbH & Co. KG; Alemania
dc.description.fil
Fil: Roscher, Jörg. Universität Münster. Institute of Inorganic and Analytical Chemistry, Westfälische Wilhelms; Alemania
dc.description.fil
Fil: Huhn, Carolin. Universität Tübingen. Institute of Physical and Theoretical Chemistry, Eberhard Karls ; Alemania. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.journal.title
Analytical and Bioanalytical Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00216-014-8074-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1007/s00216-014-8074-3


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