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dc.contributor.author Woltmann, Eva
dc.contributor.author Meyer, Hans
dc.contributor.author Weigel, Diana
dc.contributor.author Pritzke, Heinz
dc.contributor.author Posch, Tjorben N.
dc.contributor.author Kler, Pablo Alejandro
dc.contributor.author Schürmann, Klaus
dc.contributor.author Roscher, Jörg
dc.contributor.author Huhn, Carolin
dc.date.available 2017-07-07T20:34:47Z
dc.date.issued 2014-10
dc.identifier.citation Woltmann, Eva; Meyer, Hans; Weigel, Diana; Pritzke, Heinz; Posch, Tjorben N.; et al.; Applicability of UV-laser-induced solid-state fluorescence spectroscopy for the characterization solid dosage forms; Springer; Analytical and Bioanalytical Chemistry; 406; 25; 10-2014; 6347-6362
dc.identifier.issn 1618-2642
dc.identifier.uri http://hdl.handle.net/11336/19919
dc.description.abstract High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization of an instrumental setup for rapid and non-invasive characterization of tablets by laser-induced fluorescence spectroscopy (with a UV-laser (λ ex = 266 nm) as excitation source) in reflection geometry. The setup was first validated with regard to repeatability, bleaching phenomena, and sensitivity. The effect on the spectra by the physical and chemical properties of the samples, e.g. their hardness, homogeneity, chemical composition, and granule grain size of the uncompressed material, using a series of tablets, manufactured in accordance with design of experiments, was investigated. Investigation of tablets with regard to homogeneity, especially, is extremely important in pharmaceutical production processes. We demonstrate that multiplicative scatter correction is an appropriate tool for data preprocessing of fluorescence spectra. Tablets with different physical and chemical characteristics can be discriminated well from their fluorescence spectra by subjecting the results to principal component analysis.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Tablet analysis
dc.subject Solid-state fluorescence spectroscopy
dc.subject Grain size
dc.subject Photobleaching
dc.subject Scattering effects
dc.subject Homogeneity
dc.subject.classification Química Analítica
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Applicability of UV-laser-induced solid-state fluorescence spectroscopy for the characterization solid dosage forms
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-03T19:51:41Z
dc.journal.volume 406
dc.journal.number 25
dc.journal.pagination 6347-6362
dc.journal.pais Alemania
dc.journal.ciudad Berlín
dc.description.fil Fil: Woltmann, Eva. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil Fil: Meyer, Hans. J&M Analytik AG; Alemania
dc.description.fil Fil: Weigel, Diana. Federal Criminal Police Office, Forensic Science Institute, KT 34 – Toxicology; Alemania
dc.description.fil Fil: Pritzke, Heinz. Glatt Systemtechnik GmbH; Alemania
dc.description.fil Fil: Posch, Tjorben N.. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil Fil: Kler, Pablo Alejandro. Universität Tübingen. Institute of Physical and Theoretical Chemistry, Eberhard Karls ; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones En Metodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones En Metodos Computacionales; Argentina. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.description.fil Fil: Schürmann, Klaus. LabCognition Analytical Software GmbH & Co. KG; Alemania
dc.description.fil Fil: Roscher, Jörg. Universität Münster. Institute of Inorganic and Analytical Chemistry, Westfälische Wilhelms; Alemania
dc.description.fil Fil: Huhn, Carolin. Universität Tübingen. Institute of Physical and Theoretical Chemistry, Eberhard Karls ; Alemania. Central Institute for Engineering, Electronics and Analytics: Analytics (ZEA-3); Alemania
dc.journal.title Analytical and Bioanalytical Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00216-014-8074-3
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1007/s00216-014-8074-3


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)