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Artículo

Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo

Escobar, Franco MatiasIcon ; Cariddi, Laura NoeliaIcon ; Sabini, Maria CarolaIcon ; Reinoso, Elina BeatrízIcon ; Sutil, Sonia Beatriz; Torres, Cristina Vanesa; Zanon, Silvia Matilde; Sabini, Liliana Inés
Fecha de publicación: 09/2012
Editorial: Pergamon-Elsevier Science Ltd
Revista: Food and Chemical Toxicology
ISSN: 0278-6915
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Minthostachys verticillata (peperina) is an aromatic and medicinal plant with several uses and ethnobotanical properties. Numerous studies have demonstrated that its essential oil (Mv-EO) presents antimicrobial capacity and shows immunomodulating and anti-allergic properties in human cell lines. Thus, the goal of this study was to investigate the main chemical composition, analyzed by GC?FID, and the cyto-genotoxic effects of Mv-EO, using Vero cells, human PBMCs and mice bone marrow cells. The Mv-EO was rich in pulegone 60.5% and menthone 18.2%. Our results clearly show that Mv-EO is not cyto-genotoxic in vitro nor in vivo. It not induced cytotoxic effects, as indicated by trypan blue dye exclusion and NRU assays both in Vero cells and human PBMCs. In addition, Mv-EO (100?1000 μg/mL) not induced apoptotic effects on human PBMCs, as indicated by Hoechst staining and DNA fragmentation analysis by agarose gel electrophoresis. The in vivo assay showed that Mv-EO (25?500 mg/kg) not increased the frequency of micronucleus in bone marrow cells of mice. Further, the ratio of polychromatic/normochromatic erythrocytes was not modified. These findings suggest that Mv-EO appears to be safe as a therapeutic agent.
Palabras clave: APOPTOSIS , CYTOTOXICITY , ESSENTIAL OIL , GAS CHROMATOGRAPHY , GENOTOXICITY , MINTHOSTACHYS VERTICILLATA
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/199133
URL: http://www.sciencedirect.com/science/article/pii/S0278691512004322
DOI: http://dx.doi.org/10.1016/j.fct.2012.06.018
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Escobar, Franco Matias; Cariddi, Laura Noelia; Sabini, Maria Carola; Reinoso, Elina Beatríz; Sutil, Sonia Beatriz; et al.; Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 50; 9; 9-2012; 3062-3067
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