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dc.contributor.author
Garnero, Claudia  
dc.contributor.author
Aiassa, Virginia  
dc.contributor.author
Longhi, Marcela Raquel  
dc.date.available
2023-05-30T19:35:01Z  
dc.date.issued
2012-04  
dc.identifier.citation
Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel; Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 63; 4-2012; 74-79  
dc.identifier.issn
0731-7085  
dc.identifier.uri
http://hdl.handle.net/11336/199087  
dc.description.abstract
A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AGGREGATION  
dc.subject
CONDUCTIVITY  
dc.subject
HYDROXYPROPYL-Β-CYCLODEXTRIN  
dc.subject
SOLID-STATE ANALYSIS  
dc.subject
SULFAMETHOXAZOLE  
dc.subject.classification
Nano-materiales  
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Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-05-30T11:48:27Z  
dc.journal.volume
63  
dc.journal.pagination
74-79  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina  
dc.description.fil
Fil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina  
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina  
dc.journal.title
Journal of Pharmaceutical and Biomedical Analysis  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0731708512000155  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jpba.2012.01.011  

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