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dc.contributor.author
Fridman, Osvaldo
dc.contributor.author
Morales, Analía Verónica
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Bortoni, Laura Egle
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Turk Noceto, Paula Cecilia
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Prieto, Elio A.
dc.date.available
2023-05-30T17:31:42Z
dc.date.issued
2012-12
dc.identifier.citation
Fridman, Osvaldo; Morales, Analía Verónica; Bortoni, Laura Egle; Turk Noceto, Paula Cecilia; Prieto, Elio A.; Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney; Indian Academy of Sciences; Journal of Biosciences; 37; 1; 12-2012; 115-123
dc.identifier.issn
0250-5991
dc.identifier.uri
http://hdl.handle.net/11336/199039
dc.description.abstract
Betaine-homocysteine S-methyltransferase (BHMT) is an enzyme that converts homocysteine (Hcy) to methionine using betaine as a methyl donor. Betaine also acts as osmolyte in kidney medulla, protecting cells from high extracellular osmolarity. Hepatic BHMT expression is regulated by salt intake. Hormones, particularly corticosteroids, also regulate BHMT expression in rat liver. We investigated to know whether the corticoadrenal activity plays a role in kidney BHMT expression. BHMT activity in rat kidneys is several orders of magnitude lower than in rat livers and only restricted to the renal cortex. This study confirms that corticosteroids stimulate BHMT activity in the liver and, for the first time in an animal model, also up-regulate the BHMT gene expression. Besides, unlike the liver, corticosteroids in rat kidney down-regulate BHMT expression and activity. Given that the classical effect of adrenocortical activity on the kidney is associated with sodium and water re-absorption by the distal tubule leading to volume expansion, by promoting lesser use of betaine as a methyl donor, corticosteroids would preserve betaine for its other role as osmoprotectant against changes in the extracellular osmotic conditions. We conclude that corticosteroids are, at least in part, responsible for the inhibition of BHMT expression and activity in rat kidneys.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Indian Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BETAINE
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HOMOCYSTEINE
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METHYLATION
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OSMOLYTE
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-30T12:38:39Z
dc.journal.volume
37
dc.journal.number
1
dc.journal.pagination
115-123
dc.journal.pais
India
dc.description.fil
Fil: Fridman, Osvaldo. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Morales, Analía Verónica. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Bortoni, Laura Egle. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Turk Noceto, Paula Cecilia. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Prieto, Elio A.. Universidad Abierta Interamericana; Argentina
dc.journal.title
Journal of Biosciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12038-011-9171-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12038-011-9171-5
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