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dc.contributor.author
Frankel, Nicolás
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dc.date.available
2023-05-30T16:14:04Z
dc.date.issued
2012-12
dc.identifier.citation
Frankel, Nicolás; Multiple layers of complexity in cis-regulatory regions of developmental genes; Wiley-liss, div John Wiley & Sons Inc.; Developmental Dynamics; 241; 12; 12-2012; 1857-1866
dc.identifier.issn
1058-8388
dc.identifier.uri
http://hdl.handle.net/11336/199031
dc.description.abstract
Genomes contain the necessary information to ensure that genes are expressed in the right place, at the right time, and with the proper rate. Metazoan developmental genes often possess long stretches of DNA flanking their coding sequences and/or large introns which contain elements that influence gene expression. Most of these regulatory elements are relatively small and can be studied in isolation. For example, transcriptional enhancers, the elements that generate the expression pattern of a gene, have been traditionally studied with reporter constructs in transgenic animals. These studies have provided and will provide invaluable insights into enhancer evolution and function. However, this experimental approach has its limits; often, enhancer elements do not faithfully recapitulate native expression patterns. This fact suggests that additional information in cis-regulatory regions modulates the activity of enhancers and other regulatory elements. Indeed, recent studies have revealed novel functional aspects at the level of whole cis-regulatory regions. First, the discovery of "shadow enhancers." Second, the ubiquitous interactions between cis-regulatory elements. Third, the notion that some cis-regulatory regions may not function in a modular manner. Last, the effect of chromatin conformation on cis-regulatory activity. In this article, I describe these recent findings and discuss open questions in the field.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHROMATIN CONFORMATION
dc.subject
CIS-REGULATORY ELEMENTS
dc.subject
CIS-REGULATORY REGIONS
dc.subject
DEVELOPMENTAL GENES
dc.subject
REGULATORY-ELEMENT INTERACTION
dc.subject
SHADOW ENHANCERS
dc.subject.classification
Genética y Herencia
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Multiple layers of complexity in cis-regulatory regions of developmental genes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-29T12:15:56Z
dc.journal.volume
241
dc.journal.number
12
dc.journal.pagination
1857-1866
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
dc.journal.title
Developmental Dynamics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.23871
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dvdy.23871
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