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dc.contributor.author
Perez Lloret, Santiago
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dc.contributor.author
Rey, María Verónica
dc.contributor.author
Bondon Guitton, Emmanuelle
dc.contributor.author
Rascol, Olivier
dc.contributor.author
Montastruc, And Jean-Louis
dc.date.available
2023-05-30T14:33:27Z
dc.date.issued
2012-12
dc.identifier.citation
Perez Lloret, Santiago; Rey, María Verónica; Bondon Guitton, Emmanuelle; Rascol, Olivier; Montastruc, And Jean-Louis; Drugs associated with restless legs syndrome: A case/noncase study in the French pharmacovigilance database; Lippincott Williams; Journal of Clinical Psychopharmacology; 32; 6; 12-2012; 824-827
dc.identifier.issn
0271-0749
dc.identifier.uri
http://hdl.handle.net/11336/198969
dc.description.abstract
BACKGROUND: Several case reports have suggested that drugs could induce restless legs syndrome. However, no systematic review of this adverse drug reaction (ADR) in a pharmacovigilance database has been published. OBJECTIVE: To assess the frequency of restless legs syndrome in the French Pharmacovigilance Database. METHODS: We selected all ADR reports from January 1, 1984 to December 31, 2009 coded as restless legs syndrome. Restless legs syndrome diagnosis was validated from case descriptions. Using a case/noncase approach, reporting odds ratio and 95% confidence interval were calculated for ''suspected'' drugs with 2 or more observations. RESULTS: Twenty-six ADR reports were found. Four cases were excluded because of alternative diagnosis. Fourteen cases were women (64%). Median age was 57. Most frequently suspected drugs were antidepressants (reporting odds ratio, 15.9 [6.4-39.7]; amitriptyline, escitalopram, mianserine, mirtazapine, duloxetine), neuroleptics (17.8 [6.1-51.7]; thioridazine, loxapine, risperidone, aripiprazole) or tramadol (18.2 [6.3-52.8]). CONCLUSIONS: Restless legs syndrome is a very rare ADR that was more frequently reported in association with antidepressants, neuroleptics, or tramadol.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADVERSE DRUG REACTIONS
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DRUG-INDUCED MOVEMENT DISORDERS
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PHARMACOVIGILANCE
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RESTLESS LEGS SYNDROME
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SLEEP-RELATED MOVEMENT DISORDERS
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Drugs associated with restless legs syndrome: A case/noncase study in the French pharmacovigilance database
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-30T12:34:20Z
dc.journal.volume
32
dc.journal.number
6
dc.journal.pagination
824-827
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Perez Lloret, Santiago. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rey, María Verónica. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Bondon Guitton, Emmanuelle. Inserm; Francia
dc.description.fil
Fil: Rascol, Olivier. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Montastruc, And Jean-Louis. Inserm; Francia
dc.journal.title
Journal of Clinical Psychopharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/JCP.0b013e318272cdd8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/psychopharmacology/Fulltext/2012/12000/Drugs_Associated_With_Restless_Legs_Syndrome__A.16.aspx
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