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dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.author
Vidal, Maria Florencia
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dc.contributor.author
Vigo, Daniel Eduardo
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dc.date.available
2023-05-24T17:27:35Z
dc.date.issued
2012-11
dc.identifier.citation
Cardinali, Daniel Pedro; Vidal, Maria Florencia; Vigo, Daniel Eduardo; Agomelatine: Its Role in the Management of Major Depressive Disorder; SAGE Publications; Clinical Medicine Insights: Psychiatry; 4; 11-2012; 1-23
dc.identifier.issn
1179-5573
dc.identifier.uri
http://hdl.handle.net/11336/198640
dc.description.abstract
Circadian rhythm abnormalities, as shown by sleep/wake cycle disturbances, constitute one the most prevalent signs of depressive illness; advances or delays in the circadian phase are documented in patients with major depressive disorder (MDD), bipolar disorder, and seasonal affective disorder (SAD). The disturbances in the amplitude and phase of rhythm in melatonin secretion that occur in patients with depression resemble those seen in chronobiological disorders, thus suggesting a link between disturbed melatonin secretion and depressed mood. Based on this, agomelatine, the first MT1 /MT2 melatonergic agonist displaying also 5-HT2C serotonergic antagonism, has been introduced as an antidepressant. Agomelatine has been shown to be effective in several animal models of depression and anxiety and it has beneficial effects in patients with MDD, bipolar disorder, or SAD. Among agomelatine’s characteristics are a rapid onset of action and a pronounced effectiveness for correcting circadian rhythm abnormalities and improving the sleep/wake cycle. Agomelatine also improves the 3 functional dimensions of depression—emotional, cognitive, and social—thus aiding in the full recovery of patients to a normal life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
AGOMELATINE
dc.subject
MELATONIN RECEPTORS
dc.subject
SEROTONIN RECEPTORS
dc.subject
ANTIDEPRESSANTS
dc.subject
ANXIOLYTICS
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Agomelatine: Its Role in the Management of Major Depressive Disorder
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-24T14:23:49Z
dc.journal.volume
4
dc.journal.pagination
1-23
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
California
dc.description.fil
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Vidal, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina
dc.journal.title
Clinical Medicine Insights: Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.4137/CMPsy.S7989
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4137/CMPsy.S7989
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