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dc.contributor.author
Vaccaro, Maria Ines
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dc.date.available
2023-05-24T10:23:07Z
dc.date.issued
2012-02
dc.identifier.citation
Vaccaro, Maria Ines; Zymophagy: Selective autophagy of secretory granules; Hindawi Publishing Corporation; International Journal of Cell Biology; 2012; 05; 2-2012; 1-7
dc.identifier.issn
1687-8876
dc.identifier.uri
http://hdl.handle.net/11336/198515
dc.description.abstract
Timing is everything. That's especially true when it comes to the activation of enzymes created by the pancreas to break down food. Pancreatic enzymes are packed in secretory granules as precursor molecules called zymogens. In physiological conditions, those zymogens are activated only when they reach the gut, where they get to work releasing and distributing nutrients that we need to survive. If this process fails and the enzymes are prematurely activated within the pancreatic cell, before they are released from the gland, they break down the pancreas itself causing acute pancreatitis. This is a painful disease that ranges from a mild and autolimited process to a severe and lethal condition. Recently, we demonstrated that the pancreatic acinar cell is able to switch on a refined mechanism that could explain the autolimited form of the disease. This is a novel selective form of autophagy named zymophagy, a cellular process to specifically detect and degrade secretory granules containing activated enzymes before they can digest the organ. In this work, we revise the molecules and mechanisms that mediate zymophagy, a selective autophagy of secretory granules.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Zymophagy
dc.subject
VMP1
dc.subject
Autophagy
dc.subject
Acute pancreatitis
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Zymophagy: Selective autophagy of secretory granules
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-19T15:02:16Z
dc.identifier.eissn
1687-8884
dc.journal.volume
2012
dc.journal.number
05
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
International Journal of Cell Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ijcb/2012/396705/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2012/396705
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