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dc.contributor.author
Meroño, Tomás
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dc.contributor.author
Gomez Rosso, Leonardo Adrián
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dc.contributor.author
Sorroche, Patricia
dc.contributor.author
Boero, Laura
dc.contributor.author
Arbelbide, Jorge
dc.contributor.author
Brites, Fernando Daniel
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dc.date.available
2023-05-23T10:16:01Z
dc.date.issued
2011-05
dc.identifier.citation
Meroño, Tomás; Gomez Rosso, Leonardo Adrián; Sorroche, Patricia; Boero, Laura; Arbelbide, Jorge; et al.; High risk of cardiovascular disease in iron overload patients; Wiley Blackwell Publishing, Inc; European Journal of Clinical Investigation; 41; 5; 5-2011; 479-486
dc.identifier.issn
0014-2972
dc.identifier.uri
http://hdl.handle.net/11336/198390
dc.description.abstract
Introduction: Iron overload (IO) is defined as an increase in storage iron, regardless of the presence or absence of tissue damage. Whether increased iron stores are involved in the pathogenesis of cardiovascular disease remains controversial.Objectives: To study insulin resistance markers, lipoprotein profile, activities of anti and prooxidant enzymes and cholesteryl ester transfer protein (CETP) in patients with IO.Methods: Twenty patients with IO were compared with 20 sex and age-matched controls. General biochemical parameters, lipoprotein profile, and activities of paraoxonase 1, employing two substrates, paraoxon (PON) and phenylacetate (ARE), lipoprotein-associated phospholipase A2 (Lp-PLA2) and CETP were determined.Results: IO patients showed higher levels of HOMA-IR and triglycerides (median [Q1-Q3]) (128[93-193] vs. 79[51-91]mg/dl,p<0.0005) while lower HDL-cholesterol (mean±SD) (41±9 vs. 52±10mg/dl,p<0.0005) in comparison with controls. Moreover, the triglycerides/HDL-cholesterol (3.2[2.0-5.1] vs. 1.5[1.0-1.9],p<0.0005) ratio and oxidized LDL levels (94[64-103] vs. 68[59-70]IU/l,p<0.05) were increased in the patient group. Though no difference was observed in ARE activity, PON activity was decreased in IO patients (246[127-410] vs. 428[263-516]nmol.ml-1.min-1,p<0.05). In addition, CETP and Lp-PLA2 activities were also increased in the patients (189±31 vs. 155±36%.ml-1.h-1,p<0.005; and 10.1±2.9 vs. 8.2±2.4µmol.ml-1.h-1,p<0.05, respectively). Associations between ferritin concentration and the alterations in lipid metabolism were also found. Multiple regression analyses identified HOMA-IR as independent predictor of CETP activity (B=65.9,p<0.0001,r2=0.35), as well as ferritin concentration of Lp-PLA2 activity (B=3.7,p<0.0001,r2=0.40) after adjusting for confounding variables.Conclusions: IO patients presented not only insulin resistance, but also metabolic alterations which were related to elevated iron stores and are associated to high risk of cardiovascular disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATHEROSCLEROSIS
dc.subject
CHOLESTERYL ESTER TRANSFER PROTEIN
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INSULIN RESISTANCE
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IRON
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LIPOPROTEIN
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LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
High risk of cardiovascular disease in iron overload patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-04T11:37:57Z
dc.journal.volume
41
dc.journal.number
5
dc.journal.pagination
479-486
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Sorroche, Patricia. Hospital Italiano; Argentina
dc.description.fil
Fil: Boero, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
dc.description.fil
Fil: Arbelbide, Jorge. Hospital Italiano; Argentina
dc.description.fil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
European Journal of Clinical Investigation
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2362.2010.02429.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2362.2010.02429.x
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