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dc.contributor.author
Navarro, Lucila
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Mogosanu, Diana
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de Jong, Thijs
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Bakker, Astrid
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Schaubroeck, David
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Luna, Julio Alberto
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Rintoul, Ignacio
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Vanfleteren, Jan
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Dubruel, Peter
dc.date.available
2017-07-06T19:00:06Z
dc.date.issued
2016-10
dc.identifier.citation
Navarro, Lucila; Mogosanu, Diana; de Jong, Thijs; Bakker, Astrid; Schaubroeck, David; et al.; Poly (polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents; Wiley VCH Verlag; Macromolecular Bioscience; 16; 11; 10-2016; 1678-1692
dc.identifier.issn
1616-5195
dc.identifier.uri
http://hdl.handle.net/11336/19779
dc.description.abstract
Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and restenosis, require new materials to be studied. For this purpose, novel poly(polyol sebacate)-derived polymers are investigated as coatings for metallic stents. All pre-polymers reveal a low molecular weight between 3000 and 18 000 g mol−1. The cured polymers range from flexible to more rigid, with E-modulus between 0.6 and 3.8 MPa. Their advantages include straightforward synthesis, biodegradability, easy processing through different scaffolding techniques, and easy transfer to industrial production. Furthermore, electrospraying and dip-coating procedures are used as proof-of-concept to create coatings on metallic stents. Biocompatibility tests using adipose stem cells lead to promising results for the use of these materials as coatings for metallic coronary stents. (Figure presented.).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOCOMPATIBLE
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COATINGS
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METALLIC STENTS
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POLY(POLYOL-SEBACATE)S
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Poly (polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-08T19:28:12Z
dc.journal.volume
16
dc.journal.number
11
dc.journal.pagination
1678-1692
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico Para la Industria Química; Argentina
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Fil: Mogosanu, Diana. University of Ghent; Bélgica
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Fil: de Jong, Thijs. Academic Centre for Dentistry Amsterdam; Países Bajos
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Fil: Bakker, Astrid. Academic Centre for Dentistry Amsterdam; Países Bajos
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Fil: Schaubroeck, David. University of Ghent; Bélgica
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Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico Para la Industria Química; Argentina
dc.description.fil
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico Para la Industria Química; Argentina
dc.description.fil
Fil: Vanfleteren, Jan. University of Ghent; Bélgica
dc.description.fil
Fil: Dubruel, Peter. University of Ghent; Bélgica
dc.journal.title
Macromolecular Bioscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mabi.201600105/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mabi.201600105
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