Artículo
Ibuprofen molecular aggregation by direct back-face transmission steady-state fluorescence
Steinberg, Paula Yael
; Krimer, Nicolas Ivan; Sarmiento, Gabriela Pabla
; Rodríguez, Dario; Huck Iriart, Cristián
; Clemenz, Daniel; Zelcer, Andrés
; Mirenda, Martin
Fecha de publicación:
06/2022
Editorial:
Royal Society of Chemistry
Revista:
Photochemical and Photobiological Sciences
ISSN:
1474-905X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Direct back-face transmission steady-state fluorescence was successfully applied to the study of aggregation of ibuprofen and ibuprofenate anion in solution taking advantage of its own fluorescence. The analysis of the experimental data involves the use of the differential reabsorption model to account for re-absorption phenomenon and the closed association model to describe aggregation. The fluorescence quantum yield of ibuprofenate increases when it aggregates in the presence of sodium, but it markedly decreases when 1-butyl-3-methylimidazolium is used as counterion. The proposed methodology allows the accurate determination of the critical aggregation concentrations and the mean aggregation numbers. Results were supported by complementary techniques such as time-resolved fluorescence, 1H-NMR and small-angle neutron and X-ray scattering. The developed technique constitutes a promising strategy to characterize the aggregation of poorly fluorescent surfactants that aggregates at high concentrations and hence at high absorbance values, conditions in which the most common right-angle configuration for fluorescence acquisition is troublesome due to re-absorption.
Palabras clave:
IBUPROFEN
,
FLUORESCENCE QUANTUM YIELD
,
AMPHIPATHIC MOLECULES
,
AGGREGATION
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Articulos(CIBION)
Articulos de CENTRO DE INVESTIGACIONES EN BIONANOCIENCIAS "ELIZABETH JARES ERIJMAN"
Articulos de CENTRO DE INVESTIGACIONES EN BIONANOCIENCIAS "ELIZABETH JARES ERIJMAN"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Steinberg, Paula Yael; Krimer, Nicolas Ivan; Sarmiento, Gabriela Pabla; Rodríguez, Dario; Huck Iriart, Cristián; et al.; Ibuprofen molecular aggregation by direct back-face transmission steady-state fluorescence; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 6-2022; 1-9
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