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dc.contributor.author
Tirado González, Irene
dc.contributor.author
Barrientos, Gabriela Laura
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Freitag, Nancy
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Otto, Teresa
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Thijssen, Victor L. J. L.
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Moschansky, Petra
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von Kwiatkowski, Petra
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Klapp, Burghard F.
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Winterhager, Elke
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Bauersachs, Stefan
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Blois, Sandra M.
dc.date.available
2023-05-15T15:01:05Z
dc.date.issued
2012-10
dc.identifier.citation
Tirado González, Irene; Barrientos, Gabriela Laura; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L. J. L.; et al.; Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression; Public Library of Science; Plos One; 7; 10; 10-2012; 467551-4675510
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/197534
dc.description.abstract
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
natural killer cells
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dendritic cells
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mouse pregnancy
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-15T14:06:11Z
dc.journal.volume
7
dc.journal.number
10
dc.journal.pagination
467551-4675510
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Tirado González, Irene. Humboldt-Universität zu Berlin; Alemania
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Fil: Barrientos, Gabriela Laura. Humboldt-Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
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Fil: Freitag, Nancy. Humboldt-Universität zu Berlin; Alemania
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Fil: Otto, Teresa. Universitat Essen; Alemania
dc.description.fil
Fil: Thijssen, Victor L. J. L.. Humboldt-Universität zu Berlin; Alemania
dc.description.fil
Fil: Moschansky, Petra. Humboldt-Universität zu Berlin; Alemania
dc.description.fil
Fil: von Kwiatkowski, Petra. Humboldt-Universität zu Berlin; Alemania
dc.description.fil
Fil: Klapp, Burghard F.. Humboldt-Universität zu Berlin; Alemania
dc.description.fil
Fil: Winterhager, Elke. Universitat Essen; Alemania
dc.description.fil
Fil: Bauersachs, Stefan. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Blois, Sandra M.. Humboldt-Universität zu Berlin; Alemania
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046755
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0046755
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