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dc.contributor.author
Lopez Bergami, Pablo Roberto
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dc.date.available
2023-05-09T13:12:36Z
dc.date.issued
2022-12
dc.identifier.citation
Lopez Bergami, Pablo Roberto; ROR2, a driver of “phenotype switching” in melanoma?; BioMed Central; Cancer Cell International; 22; 1; 12-2022; 1-4
dc.identifier.issn
1475-2867
dc.identifier.uri
http://hdl.handle.net/11336/196763
dc.description.abstract
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of “phenotype switching” in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CELL PLASTICITY
dc.subject
EPITHELIAL TO MESENCHYMAL TRANSITION
dc.subject
MELANOMA
dc.subject
PHENOTYPE SWITCHING
dc.subject
ROR2
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
ROR2, a driver of “phenotype switching” in melanoma?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-09T11:47:59Z
dc.journal.volume
22
dc.journal.number
1
dc.journal.pagination
1-4
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Lopez Bergami, Pablo Roberto. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Cancer Cell International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12935-022-02711-x
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