Mostrar el registro sencillo del ítem
dc.contributor.author
Perez Lloret, Santiago
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Rey, María Verónica
dc.contributor.author
Fabre, Nelly
dc.contributor.author
Ory, Fabienne
dc.contributor.author
Spampinato, Umberto
dc.contributor.author
Senard, Jean Michel
dc.contributor.author
Pavy Le Traon, Anne
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Montastruc, Jean Louis
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Rascol, Olivier
dc.date.available
2023-05-05T15:51:22Z
dc.date.issued
2012-06
dc.identifier.citation
Perez Lloret, Santiago; Rey, María Verónica; Fabre, Nelly; Ory, Fabienne; Spampinato, Umberto; et al.; Factors related to orthostatic hypotension in Parkinson's disease; Elsevier; Parkinsonism & Related Disorders; 18; 5; 6-2012; 501-505
dc.identifier.issn
1353-8020
dc.identifier.uri
http://hdl.handle.net/11336/196465
dc.description.abstract
Introduction: Orthostatic hypotension (OH), a frequent feature of Parkinson's disease (PD) can contribute to falls and is usually related to the disease itself and/or to drugs. Objectives: To explore factors related to OH and to assess the concordance between abnormal blood pressure (BP) fall after standing and the presence of orthostatic symptoms. Methods: Non-demented, non-operated idiopathic PD out-patients were questioned about the presence of orthostatic symptoms. Afterward, BP was measured 5-min after lying down and for 3-min after standing up. OH was defined as systolic and/or diastolic BP fall ≥20 and/or 10. mmHg after standing. Patients were further evaluated by the Unified PD Rating Scale (UPDRS) and their medications were recorded. Results: 103 patients were included in this study (mean age = 66 ± 1 years, mean disease duration = 9 ± 1 years; mean UPDRS II. +. III in ON-state = 37 ± 2 points). Forty-one subjects (40%) reported the presence of orthostatic symptoms during the previous week and 38 (37%) had OH according to manometric definition. Independent factors related to OH, as assessed by logistic regression were age >68 years (OR, 95% CI = 3.61, 1.31-9.95), polypharmacy (defined as intake of >5 medications, OR = 3.59, 1.33-9.69), amantadine (7.45, 1.91-29.07) or diuretics (5.48, 1.10-54.76), whereas the consumption of entacapone was protective (0.20, 0.05-0.76). The agreement between abnormal BP fall and presence of orthostatic symptoms was poor (kappa = 0.12 ± 0.1, p= 0.23). Conclusion: OH was significantly related to older age, polypharmacy and amantadine or diuretics intake, while entacapone exposure appeared to reduce the risk of OH. Low concordance between OH and orthostatic symptoms was observed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGING
dc.subject
AMANTADINE
dc.subject
DIURETICS
dc.subject
ENTACAPONE
dc.subject
NON-MOTOR SYMPTOMS
dc.subject
ORTHOSTATIC HYPOTENSION
dc.subject
PARKINSON'S DISEASE
dc.subject
POLYPHARMACY
dc.subject.classification
Neurología Clínica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Clínica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Factors related to orthostatic hypotension in Parkinson's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-05T12:53:31Z
dc.journal.volume
18
dc.journal.number
5
dc.journal.pagination
501-505
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Perez Lloret, Santiago. Inserm; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rey, María Verónica. Inserm; Francia
dc.description.fil
Fil: Fabre, Nelly. Hôpital Purpan; Francia
dc.description.fil
Fil: Ory, Fabienne. Hôpital Purpan; Francia
dc.description.fil
Fil: Spampinato, Umberto. Inserm; Francia
dc.description.fil
Fil: Senard, Jean Michel. Inserm; Francia
dc.description.fil
Fil: Pavy Le Traon, Anne. Hôpital Purpan; Francia
dc.description.fil
Fil: Montastruc, Jean Louis. Inserm; Francia
dc.description.fil
Fil: Rascol, Olivier. Inserm; Francia
dc.journal.title
Parkinsonism & Related Disorders
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.prd-journal.com/article/S1353-8020(12)00030-2/fulltext
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.parkreldis.2012.01.012
Archivos asociados