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dc.contributor.author
Gabriele, Amanda
dc.contributor.author
Pacchioni, Alejandra Maria
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dc.contributor.author
See, Ronald E.
dc.date.available
2023-05-05T14:18:34Z
dc.date.issued
2012-12
dc.identifier.citation
Gabriele, Amanda; Pacchioni, Alejandra Maria; See, Ronald E.; Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats; Pergamon-Elsevier Science Ltd; Pharmacology Biochemistry and Behavior; 103; 2; 12-2012; 373-379
dc.identifier.issn
0091-3057
dc.identifier.uri
http://hdl.handle.net/11336/196433
dc.description.abstract
Evidence suggests that cocaine addiction may involve progressive neuroadaptive changes in the dorsolateral caudate putamen (dlCPu). While cocaine seeking following abstinence from chronic self-administration requires intact dlCPu function, in vivo neurotransmitter release in the dlCPu has not been investigated. The current study measured dlCPu dopamine (DA) and glutamate (GLU) release during drug seeking following limited or extended abstinence, as well as in response to a cocaine priming injection alone. Male, Sprague–Dawley rats self-administered cocaine (0.2 mg/50 μl infusion, i.v.) for 10 days (2 h/day). In vivo microdialysis occurred in the self-administration chamber after 1 and 14 days of abstinence (Experiment 1). A separate set of animals that completed self-administration as well as drug naïve controls received a cocaine priming injection (20 mg/kg) during concurrent microdialysis (Experiment 2). DA release increased during drug seeking in the self-administration context at both 1 and 14 days post abstinence. In contrast, GLU release only increased after 1 day of abstinence. Furthermore, animals with a cocaine self-administration history showed enhanced DA and GLU release following cocaine challenge as compared to drug naïve controls. These results indicate that chronic cocaine self-administration enhances dlCPu DA and GLU under both drug-paired context and drug-primed conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COCAINE
dc.subject
DOPAMINE
dc.subject
DORSAL
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GLUTAMATE
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SELF-ADMINISTRATION
dc.subject
STRIATUM
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-23T12:39:58Z
dc.journal.volume
103
dc.journal.number
2
dc.journal.pagination
373-379
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Gabriele, Amanda. Medical University Of South Carolina; Estados Unidos
dc.description.fil
Fil: Pacchioni, Alejandra Maria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: See, Ronald E.. Medical University Of South Carolina; Estados Unidos
dc.journal.title
Pharmacology Biochemistry and Behavior
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pbb.2012.09.015
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