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dc.contributor.author Fabrizio, M. C.
dc.contributor.author Schweigmann, Nicolas Joaquin
dc.contributor.author Bartoloni, Norberto Jose
dc.date.available 2017-07-05T17:53:42Z
dc.date.issued 2014-05
dc.identifier.citation Fabrizio, M. C.; Schweigmann, Nicolas Joaquin; Bartoloni, Norberto Jose; Modelling inter-human transmission dynamics of Chagas disease: analysis and application; Cambridge University Press; Parasitology; 141; 6; 5-2014; 837-848
dc.identifier.issn 0031-1820
dc.identifier.uri http://hdl.handle.net/11336/19610
dc.description.abstract Transmission of Trypanosoma cruzi, the causal agent of Chagas disease, has expanded from rural endemic to urban areas due to migration. This so-called urban Chagas is an emerging health problem in American, European, Australian and Japanese cities. We present a mathematical model to analyse the dynamics of urban Chagas to better understand its epidemiology. The model considers the three clinical stages of the disease and the main routes of inter-human transmission. To overcome the complexities of the infection dynamics, the next-generation matrix method was developed. We deduced expressions which allowed estimating the number of new infections generated by an infected individual through each transmission route at each disease stage, the basic reproduction number and the number of individuals at each disease stage at the outbreak of the infection. The analysis was applied to Buenos Aires city (Argentina). We estimated that 94% of the new infections are generated by individuals in the chronic indeterminate stage. When migration was not considered, the infection disappeared slowly and R0 = 0·079, whereas when migration was considered, the number of individuals in each stage of the infection tended to stabilize. The expressions can be used to estimate different numbers of infected individuals in any place where only inter-human transmission is possible.
dc.format application/pdf
dc.language.iso eng
dc.publisher Cambridge University Press
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Urban Chagas
dc.subject Next-generation matrix
dc.subject Basic reproduction number
dc.subject Mathematical model
dc.subject.classification Ecología
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Modelling inter-human transmission dynamics of Chagas disease: analysis and application
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-05T15:02:35Z
dc.journal.volume 141
dc.journal.number 6
dc.journal.pagination 837-848
dc.journal.pais Reino Unido
dc.journal.ciudad Cambridge
dc.description.fil Fil: Fabrizio, M. C.. Universidad de Buenos Aires. Facultad de Agronomia; Argentina
dc.description.fil Fil: Schweigmann, Nicolas Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
dc.description.fil Fil: Bartoloni, Norberto Jose. Universidad de Buenos Aires. Facultad de Agronomia; Argentina
dc.journal.title Parasitology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0031182013002199
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/modelling-interhuman-transmission-dynamics-of-chagas-disease-analysis-and-application/31B84D8DEDC8046D86A41A289B7E69CF


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)