Artículo
Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens
Zanetti, Flavia Adriana
; del Medico Zajac, Maria Paula
; Taboga, Oscar Alberto
; Calamante, Gabriela
Fecha de publicación:
06/2012
Editorial:
Korean Society of Veterinary Science
Revista:
Journal of Veterinary Science
ISSN:
1229-845X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response by observing the production of anti-IBDV-seroneutralizing antibodies in specific pathogen-free chickens. Besides, as the epitopes of VP2 responsible to induce IBDV-neutralizing antibodies are discontinuous, our results suggest that VP2 protein expressed from MVA-VP2 maintained the correct conformational structure. To our knowledge, this is the first report on the usefulness of MVA-based vectors for developing recombinant vaccines for poultry.
Palabras clave:
CHICKEN IMMUNITY
,
IBDV
,
MVA
,
VP2 PROTEIN
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Zanetti, Flavia Adriana; del Medico Zajac, Maria Paula; Taboga, Oscar Alberto; Calamante, Gabriela; Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens; Korean Society of Veterinary Science; Journal of Veterinary Science; 13; 2; 6-2012; 199-201
Compartir
Altmétricas