Artículo
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; Martin Sanz, Paloma; Fernández Alvarez, Ana Julia
; Casado, Marta
; Casado, Marta
Fecha de publicación:
02/2013
Editorial:
Elsevier
Revista:
Biochemical And Biophysical Research Communications
ISSN:
0006-291X
e-ISSN:
1090-2104
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
Palabras clave:
Pfk
,
Fetal Liver
,
Splicing
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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; et al.; Identification of a novel Pfkfb1 mRNA variant in rat fetal liver; Elsevier; Biochemical And Biophysical Research Communications; 431; 1; 2-2013; 36-40
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