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Artículo

The bacterial protein Hfq: Much more than a mere RNA-binding factor

Sobrero, Patricio MartínIcon ; Valverde, Claudio FabiánIcon
Fecha de publicación: 03/2012
Editorial: Taylor & Francis
Revista: Critical Reviews In Microbiology
ISSN: 1040-841X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally identified in Escherichia coli as a host factor required for replication of the Qβ RNA phage. In this review, we present a comprehensive summary of 40 years of investigation to learn that Hfq is an influential, though not essential, global regulator of gene expression in bacteria and that this feature is undoubtedly linked to Hfq's RNA-binding properties. This protein intervenes in different RNA transactions, notably the promotion of antisense interactions between messenger RNAs and small regulatory RNAs. Yet, several aspects of its molecular mechanism remain not understood. In addition, mechanistic studies have been exclusively carried out in enterobacterial models, highlighting the need to expand the research on Hfq function to other taxons. Upon reviewing the genetic, structural, biochemical, and biological aspects of this extraordinary protein, we discuss recent findings on interactions with macromolecules other than RNA suggesting a broader participation of Hfq in major steps in the flow of genetic information. We show that, although significant progress has been achieved to elucidate Hfq role at the molecular level, many open questions remain.
Palabras clave: GLOBAL REGULATOR , HFQ , NUCLEIC ACID BINDING PROTEIN , SM-PROTEIN , SRNAMRNA INTERACTIONS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/195339
URL: https://www.tandfonline.com/doi/full/10.3109/1040841X.2012.664540
DOI: http://dx.doi.org/10.3109/1040841X.2012.664540
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Citación
Sobrero, Patricio Martín; Valverde, Claudio Fabián; The bacterial protein Hfq: Much more than a mere RNA-binding factor; Taylor & Francis; Critical Reviews In Microbiology; 38; 4; 3-2012; 276-299
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