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dc.contributor.author
Valeff, Natalin Jimena  
dc.contributor.author
Abba, Martin C.  
dc.contributor.author
Jensen, Federico  
dc.date.available
2023-04-21T13:53:53Z  
dc.date.issued
2021  
dc.identifier.citation
B1 B cells acquire a proliferative and anti-inflammatory profile during pregnancy in mice; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 121-121  
dc.identifier.issn
1669-9106  
dc.identifier.uri
http://hdl.handle.net/11336/194886  
dc.description.abstract
B1 B cells are a distinct subpopulation of B cells characterized by their unique capacity of self-renewal and the ability to secrete IgM without foreign antigen exposure (natural antibodies). In addition, upon activation, B1 B cells produce large quantities of the potent anti-inflammatory cytokine IL-10. Though the mechanisms that control natural antibodies production are not fully elucidated, it was recently associated with a down-regulation of CD1d expression in B1 B cells. Taking into account that both, IL-10 and natural antibodies are known to be fundamental components in pregnancy wellbeing, the aim of this study was to evaluate proliferation status as well as CD1d expression and IL-10 production by B1 B cells during pregnancy. Flow cytometry analysis, on splenic B1 B cells from pregnant (P) and non-pregnant (NP) mice was performed to evaluate ki-67 (proliferation marker) and CD1d expression as well as IL-10 production upon LPS stimulation. We observed significantly higher expression levels of Ki-67 in splenic B1 B cells from P compared to NP (Unpaired t-test p<0,0001; n=3) mice which was mirrored by higher percentages of B1 B cells in the spleen of P mice (Unpaired t-test p=0,0095; n=11). In addition, B1 B cells from P mice expressed lower levels of CD1d as compared to NP mice (Unpaired t-test p<0,0001; n=3). Furthermore, LPS-stimulated B1 B cells from P mice produced significantly higher levels of IL-10 compared to NP mice in vitro (Unpaired t-test p=0,015; n=5).Overall, our results demonstrate that not only B1 B cells are expanded in the spleen during pregnancy but they also seem to acquire the capacity to produce higher levels of natural antibodies and IL-10 during this period, suggesting their critical role in the intricate process of pregnancy tolerance.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Fundación Revista Medicina  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
B1 cells  
dc.subject
pregnancy  
dc.subject
anti-inflamatory  
dc.subject
proliferative profile  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
B1 B cells acquire a proliferative and anti-inflammatory profile during pregnancy in mice  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/conferenceObject  
dc.type
info:ar-repo/semantics/documento de conferencia  
dc.date.updated
2022-11-25T00:27:02Z  
dc.journal.pagination
121-121  
dc.journal.pais
Argentina  
dc.journal.ciudad
Buenos Aires  
dc.description.fil
Fil: Valeff, Natalin Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina  
dc.description.fil
Fil: Abba, Martin C.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina  
dc.description.fil
Fil: Jensen, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://medicinabuenosaires.com/revistas/vol81-21/s3/Mv81s3.pdf  
dc.conicet.rol
Autor  
dc.conicet.rol
Autor  
dc.conicet.rol
Autor  
dc.coverage
Nacional  
dc.type.subtype
Reunión  
dc.description.nombreEvento
LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas  
dc.date.evento
2021-11-17  
dc.description.ciudadEvento
Buenos Aires  
dc.description.paisEvento
Argentina  
dc.type.publicacion
Journal  
dc.description.institucionOrganizadora
Sociedad Argentina de Investigación Clínica  
dc.description.institucionOrganizadora
Sociedad Argentina de Inmunología  
dc.description.institucionOrganizadora
Asociación Argentina de Farmacología Experimental  
dc.description.institucionOrganizadora
Asociación Argentina de Nanomedicinas  
dc.source.revista
Medicina  
dc.date.eventoHasta
2021-11-20  
dc.type
Reunión