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dc.contributor.author
Mark, Felix C.
dc.contributor.author
Lucassen, Magnus
dc.contributor.author
Strobel, Anneli
dc.contributor.author
Barrera Oro, Esteban
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dc.contributor.author
Koschnick, Nils
dc.contributor.author
Zane, Lorenzo
dc.contributor.author
Patarnello, Tomaso
dc.contributor.author
Pörtner, Hans O.
dc.contributor.author
Papetti, Chiara
dc.date.available
2023-04-21T11:05:23Z
dc.date.issued
2012-02
dc.identifier.citation
Mark, Felix C.; Lucassen, Magnus; Strobel, Anneli; Barrera Oro, Esteban; Koschnick, Nils; et al.; Mitochondrial function in antarctic nototheniids with ND6 translocation; Public Library of Science; Plos One; 7; 2; 2-2012; 1-12
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/194850
dc.description.abstract
Fish of the suborder Notothenioidei have successfully radiated into the Southern Ocean and today comprise the dominant fish sub-order in Antarctic waters in terms of biomass and species abundance. During evolution in the cold and stable Antarctic climate, the Antarctic lineage of notothenioids developed several unique physiological adaptations, which make them extremely vulnerable to the rapid warming of Antarctic waters currently observed. Only recently, a further phenomenon exclusive to notothenioid fish was reported: the translocation of the mitochondrial gene encoding the NADH Dehydrogenase subunit 6 (ND6), an indispensable part of complex I in the mitochondrial electron transport system. This study investigated the potential physiological consequences of ND6 translocation for the function and thermal sensitivity of the electron transport system in isolated liver mitochondria of the two nototheniid species Notothenia coriiceps and Notothenia rossii, with special attention to the contributions of complex I (NADH DH) and complex II (Succinate DH) to oxidative phosphorylation. Furthermore, enzymatic activities of NADH:Cytochrome c Oxidoreductase and Cytochrome C Oxidase were measured in membrane-enriched tissue extracts. During acute thermal challenge (0-15°C), capacities of mitochondrial respiration and enzymatic function in the liver could only be increased until 9°C. Mitochondrial complex I (NADH Dehydrogenase) was fully functional but displayed a higher thermal sensitivity than the other complexes of the electron transport system, which may specifically result from its unique amino acid composition, revealing a lower degree of stability in notothenioids in general. We interpret the translocation of ND6 as functionally neutral but the change in amino acid sequence as adaptive and supportive of cold stenothermy in Antarctic nototheniids. From these findings, an enhanced sensitivity to ocean warming can be deduced for Antarctic notothenioid fish.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aerobic energy metabolism
dc.subject
Notothenia rossii
dc.subject
Notothenia coriiceps
dc.subject
mitochondria
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Mitochondrial function in antarctic nototheniids with ND6 translocation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-20T16:06:15Z
dc.journal.volume
7
dc.journal.number
2
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Mark, Felix C.. Alfred Wegener Institut; Alemania
dc.description.fil
Fil: Lucassen, Magnus. Alfred Wegener Institut; Alemania
dc.description.fil
Fil: Strobel, Anneli. Alfred Wegener Institut; Alemania
dc.description.fil
Fil: Barrera Oro, Esteban. Ministerio de Relaciones Exteriores, Comercio Internacional y Culto. Direccion Nacional del Antártico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Koschnick, Nils. No especifíca;
dc.description.fil
Fil: Zane, Lorenzo. Università di Padova; Italia
dc.description.fil
Fil: Patarnello, Tomaso. Università di Padova; Italia
dc.description.fil
Fil: Pörtner, Hans O.. No especifíca;
dc.description.fil
Fil: Papetti, Chiara. Università di Padova; Italia
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031860
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0031860
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