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dc.contributor.author
Strejilevich, Sergio  
dc.contributor.author
Teitelbaum, J.  
dc.contributor.author
Martino, Diego Javier  
dc.contributor.author
Quiroz, D.  
dc.contributor.author
Kapczinski, F.  
dc.date.available
2023-04-19T12:47:25Z  
dc.date.issued
2012-01  
dc.identifier.citation
Strejilevich, Sergio; Teitelbaum, J.; Martino, Diego Javier; Quiroz, D.; Kapczinski, F.; Dopamine sudden depletion as a model for mixed depression; Churchill Livingstone; Medical Hypotheses; 78; 1; 1-2012; 107-112  
dc.identifier.issn
0306-9877  
dc.identifier.uri
http://hdl.handle.net/11336/194496  
dc.description.abstract
Up to date research on Bipolar Disorders' phenomenology is in keeping with early descriptions made by E. Kraëpelin regarding the overlap in clinical presentation of both manic and depressive symptoms, namely, mixed states. The latter constitute a highly prevalent and characteristic clinical presentation of Bipolar Disorders' and entail therapeutic difficulties, prognostic implications and increased suicidal risk. Notwithstanding, mixed states', more specifically mixed depression, have been underestimated and bypassed to the point where currently neither diagnostic criteria nor specific therapeutic recommendations are provided. In addition to the lack of agreement on nosography and diagnostic criteria, mixed depression is usually excluded from Bipolar Disorders' neurobiological models. Furthermore, renewed interest in the role of dopamine in Bipolar Disorders' physiopathology has left aside hypothesis that may account for the aforementioned clinical presentation. Interestingly enough, other syndromes arising from sudden dopamine depletion such as neuroleptic dysphoria or withdrawal syndromes from dopaminergic drugs, bear remarkable clinical similarities with mixed depression. These syndromes have been subject of further research and may thus provide a model for mixed states' physiopathology.Indeed, this article accounts for clinical similarities between mixed depression, neuroleptic induced dysphoria, and other behavioural syndromes arising from sudden dopamine depletion. After reviewing neurochemical basis of such syndromes we present, to the best of our knowledge, the first neurobiological hypothesis for mixed depression. Specifically, such hypothesis regards over activation symptoms as auto regulatory attempts to compensate for sudden dopaminergic depletion. This hypothesis provides with a beginning step for the neglected problem of mixed depression, a non-antithetic link between the dopaminergic hypothesis for both manic and depressive symptoms, a plausible explanation regarding inter individual variability to mixed depression susceptibility, and suggests new approaches for the development of novel treatments in which dopamine dysregulation should be targeted.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Churchill Livingstone  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
bipolar disorder  
dc.subject
mixed depression  
dc.subject
dopamine  
dc.subject.classification
Psiquiatría  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Dopamine sudden depletion as a model for mixed depression  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-04-18T13:12:50Z  
dc.journal.volume
78  
dc.journal.number
1  
dc.journal.pagination
107-112  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Strejilevich, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina  
dc.description.fil
Fil: Teitelbaum, J.. Instituto de Neurología Cognitiva; Argentina  
dc.description.fil
Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Quiroz, D.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina  
dc.description.fil
Fil: Kapczinski, F.. No especifíca;  
dc.journal.title
Medical Hypotheses  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306987711005172  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mehy.2011.10.004