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dc.contributor.author
Fernández Mateos, Pilar
dc.contributor.author
Jiménez Ortega, Vanesa
dc.contributor.author
Cano Barquilla, Pilar
dc.contributor.author
Cardinali, Daniel Pedro
dc.contributor.author
Esquifino, Ana I.
dc.date.available
2023-04-19T10:42:09Z
dc.date.issued
2012-01
dc.identifier.citation
Fernández Mateos, Pilar; Jiménez Ortega, Vanesa; Cano Barquilla, Pilar; Cardinali, Daniel Pedro; Esquifino, Ana I.; Discontinuous versus continuous drinking of ethanol in peripubertal rats: Effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress; Karger; Neuroendocrinology; 96; 3; 1-2012; 194-203
dc.identifier.issn
0028-3835
dc.identifier.uri
http://hdl.handle.net/11336/194450
dc.description.abstract
Aims: Discontinuous (weekend) consumption of alcohol is common in adolescents and young adults. This study therefore assesses, in peripubertal male rats, the effect of discontinuous as compared to chronic feeding of ethanol or control liquid diet. Methods: Animals received an ethanol liquid diet (6.2 % w/v) starting on day 35 of life. Every week for 5 weeks, the discontinuous ethanol group received the ethanol diet for 3 consecutive days and the control liquid diet for 4 days. At the 5th week, 24 h after the last ethanol administration to the discontinuously ethanol-treated animals, rats were killed at 4-hour intervals beginning at 09.00 h. Chronically administered rats received the ethanol diet until immediately before study. Results: Disrupted 24-hour rhythmicity together with a significant nocturnal increase in plasma luteinizing hormone (LH), testosterone and prolactin (PRL) occurred in the discontinuous ethanol group. Plasma ethanol levels were undetectable at 24 h after the last ethanol treatment. In contrast, after chronic ethanol administration, plasma PRL was increased late in scotophase while LH and testosterone decreased; blood ethanol levels were 2-fold greater than those in discontinuously ethanol-administered rats killed immediately after ethanol withdrawal. Circulating testosterone positively correlated with LH levels in control rats only. Chronic administration of ethanol significantly augmented mean expression of pituitary nitric oxide synthase (NOS)-2, heme oxygenase (HO)-1, Per1 and Per2 genes and disrupted their diurnal rhythmicity. Decreased NOS-1 and NOS-2 expression during scotophase, together with suppression of the rhythm in Per1 and Per2 expression, were found in the discontinuous ethanol group. Conclusions: Abstinence after discontinuous drinking of alcohol in rats, as compared to chronic administration of ethanol, is accompanied by increases of plasma LH and testosterone, a greater PRL response and a less pronounced oxidative damage of the anterior pituitary.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALCOHOLISM
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ANTERIOR PITUITARY
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CHRONIC ALCOHOL
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CLOCK GENES
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HYPOTHALAMIC-PITUITARY-GONADAL AXIS
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LIBIDO
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OXIDATIVE STRESS
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PROLACTIN
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REPRODUCTION
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THYROID-STIMULATING HORMONE
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Discontinuous versus continuous drinking of ethanol in peripubertal rats: Effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-18T13:13:54Z
dc.journal.volume
96
dc.journal.number
3
dc.journal.pagination
194-203
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Fernández Mateos, Pilar. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
dc.journal.title
Neuroendocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/334963
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000334963
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