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dc.contributor.author
Galván, Cristian A.
dc.contributor.author
Elbarcha, Osvaldo C.
dc.contributor.author
Fernández, Eduardo J.
dc.contributor.author
Beltramo, Dante Miguel
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dc.contributor.author
Soria, Néstor Walter
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dc.date.available
2023-04-14T17:28:24Z
dc.date.issued
2012-02
dc.identifier.citation
Galván, Cristian A.; Elbarcha, Osvaldo C.; Fernández, Eduardo J.; Beltramo, Dante Miguel; Soria, Néstor Walter; Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina; Mary Ann Liebert; Genetic Testing And Molecular Biomarkers; 16; 2; 2-2012; 130-133
dc.identifier.issn
1945-0265
dc.identifier.uri
http://hdl.handle.net/11336/193934
dc.description.abstract
The selection of the most appropriate treatment for several diseases relies on a number of factors such as environment, age, gender, and nutrition. Additionally, the contribution of different genetic polymorphisms to treatment efficacy has been largely recognized. The lack of information on the pharmacogenetic profile of our population prompted us to analyze the frequency of polymorphisms known to be relevant to achieve treatment efficacy with different therapeutic agents in viral infectious diseases, such as Hepatitis C and AIDS. Results: The allelic frequencies for the wild-type variant of the genes analyzed were cytochrome P450 2B6 (CYP2B6; rs3745274; 516G) 0.618 (95% confidence interval [CI]: 0.523, 0.711), chemokine coreceptor 5 (CCR5; rs333) 0.961 (95% CI: 0.942, 0.98), histocompatibility complex P5 (HCP5; rs2395029; 335T) 0.971 (95% CI: 0.937, 1), and interleukin 28B (IL28B; rs12979860; 12007005C) 0.656 (95% CI: 0.564, 0.747), respectively. Conclusions: Our data indicate that the genetic profile of the population studied is similar to that reported for other Caucasian populations, with only slight differences for CYP2B6. Noteworthy, the considerable number of patients carrying CYP2B6 (516T) and IL28B (12007005T) alleles underlies the importance of considering pharmacogenetic testing before starting drug therapy protocols to prevent toxicity and/or lack of effectiveness in AIDS or hepatitis C virus infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genetic Testing
dc.subject
Molecular Diagnosis
dc.subject
Population Screening
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-11T14:31:22Z
dc.identifier.eissn
1945-0257
dc.journal.volume
16
dc.journal.number
2
dc.journal.pagination
130-133
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Galván, Cristian A.. Universidad Católica de Córdoba; Argentina. Laboratorio de Análisis Clínicos Especializados; Argentina
dc.description.fil
Fil: Elbarcha, Osvaldo C.. Laboratorio de Análisis Clínicos Especializados; Argentina
dc.description.fil
Fil: Fernández, Eduardo J.. Laboratorio de Análisis Clínicos Especializados; Argentina
dc.description.fil
Fil: Beltramo, Dante Miguel. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Excelencia En Productos y Procesos de Cordoba; Argentina
dc.description.fil
Fil: Soria, Néstor Walter. Laboratorio de Análisis Clínicos Especializados; Argentina. Universidad Católica de Córdoba; Argentina
dc.journal.title
Genetic Testing And Molecular Biomarkers
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/21854194/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/gtmb.2011.0058
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