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dc.contributor.author
Albarellos, G. A.
dc.contributor.author
Montoya, L.
dc.contributor.author
Landoni, Maria Fabiana
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dc.date.available
2023-04-13T10:47:33Z
dc.date.issued
2011-01
dc.identifier.citation
Albarellos, G. A.; Montoya, L.; Landoni, Maria Fabiana; Pharmacokinetics of erythromycin after intravenous, intramuscular and oral administration to cats; Elsevier; The Veterinary Journal; 187; 1; 1-2011; 129-132
dc.identifier.issn
1090-0233
dc.identifier.uri
http://hdl.handle.net/11336/193603
dc.description.abstract
The aim of this study was to characterise the pharmacokinetic properties of different formulations of erythromycin in cats. Erythromycin was administered as lactobionate (4 mg/kg, intravenously (IV)), base (10 mg/kg, intramuscularly (IM)) and ethylsuccinate tablets or suspension (15 mg/kg, orally (PO)). After IV administration, the major pharmacokinetic parameters were (mean ± SD): area under the curve (AUC)(0-∞) 2.61 ± 1.52 µg.h/mL; volume of distribution (Vz) 2.34±1.76 L/kg; total body clearance (Clt) 2.10±1.37 L/h.kg; elimination half-life (t½λ) 0.75±0.09 h and mean residence time (MRT) 0.88±0.13 h. After intramuscular administration, the principal pharmacokinetic parameters were (mean ± DS): peak concentration (Cmax), 3.54±2.16 µg/mL; time of peak (Tmax), 1.22±0.67 h; t½λ, 1.94±0.21 h and MRT, 3.50±0.82 h. The administration of erythromycin ethylsuccinate (tablets and suspension) did not produce measurable serum concentrations. After IM and IV administrations, erythromycin serum concentrations were above minimum inhibitory concentration (MIC)90=0.5 µg/mL for 7 and 1.5 h, respectively. However, these results should be cautiously interpreted since tissue erythromycin concentrations have not been measured and, it is recognised that they can reach much higher concentrations than in blood, correlating better with clinical efficacy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIBIOTICS
dc.subject
ANTIMICROBIALS
dc.subject
CATS
dc.subject
ERYTHROMYCIN
dc.subject
MACROLIDES
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Pharmacokinetics of erythromycin after intravenous, intramuscular and oral administration to cats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-10T10:16:32Z
dc.journal.volume
187
dc.journal.number
1
dc.journal.pagination
129-132
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Albarellos, G. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Montoya, L.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
The Veterinary Journal
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023309003840
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tvjl.2009.09.019
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