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dc.contributor.author
Finkelstein, Yaron  
dc.contributor.author
Soon, Gordon S.  
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Acuna, Patrick  
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George, Mathew  
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Pope, Elena  
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Ito, Shinya  
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Shear, Neil H.  
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Koren, Gideon  
dc.contributor.author
Shannon, Michael W.  
dc.contributor.author
Garcia Bournissen, Facundo  
dc.date.available
2023-04-12T13:50:40Z  
dc.date.issued
2011-10  
dc.identifier.citation
Finkelstein, Yaron; Soon, Gordon S.; Acuna, Patrick; George, Mathew; Pope, Elena; et al.; Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children; American Academy of Pediatrics; Pediatrics; 128; 4; 10-2011; 723-728  
dc.identifier.issn
0031-4005  
dc.identifier.uri
http://hdl.handle.net/11336/193413  
dc.description.abstract
OBJECTIVES: To report clinical course, etiology, management, and long-term outcomes of children suffering from Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). METHODS: We conducted a study of all pediatric patients with SJS or TEN admitted between 2000 and 2007 to the Hospital for Sick Children and Children's Hospital Boston, and particular attention was paid to clinical manifestations, etiology, mortality, and long-term outcomes. RESULTS: We identified 55 cases of SJS (n = 47), TEN (n = 5), or SJS/TEN overlap syndrome (n - 3). Drugs were identified as the most likely etiologic agent in 29 children (53%); antiepileptic drugs were the most common agents (n = 16), followed by sulfonamide antibiotics (n = 7) and chemotherapy drugs (n = 2). Acute Mycoplasma pneumoniae infection was confirmed in 12 children (22%), and herpes simplex virus was confirmed in 5 children (9%). Treatment regimens differed significantly between participating sites and included systemic antimicrobial agents (67%), systemic corticosteroids (40%), and antiviral drugs (31%). Intravenous immunoglobulin was administered to 21 children (38%), of whom 8 received concomitant systemic corticosteroids. Ten children (18%) had recurrence of SJS up to 7 years after the index episode, and 3 experienced multiple recurrences. Twenty-six children (47%) suffered long-term sequelae that mostly involved the skin and eyes. CONCLUSIONS: Mortality rate in children was lower than that reported in adults, but half of affected children suffered long-term complications. The recurrence rate of SJS was high (1 in 5), which suggests vulnerability and potential genetic predisposition. In the absence of standardized management guidelines for these conditions, treatment regimens differed significantly between participating institutions.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Academy of Pediatrics  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ADVERSE DRUG REACTIONS  
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CHILDREN  
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STEVENS-JOHNSON SYNDROME  
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TOXIC EPIDERMAL NECROLYSIS  
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Pediatría  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-04-11T11:59:45Z  
dc.journal.volume
128  
dc.journal.number
4  
dc.journal.pagination
723-728  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Finkelstein, Yaron. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; Canadá  
dc.description.fil
Fil: Soon, Gordon S.. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; Canadá  
dc.description.fil
Fil: Acuna, Patrick. Children's Hospital Boston; Estados Unidos  
dc.description.fil
Fil: George, Mathew. Children's Hospital Boston; Estados Unidos  
dc.description.fil
Fil: Pope, Elena. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; Canadá  
dc.description.fil
Fil: Ito, Shinya. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; Canadá  
dc.description.fil
Fil: Shear, Neil H.. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; Canadá  
dc.description.fil
Fil: Koren, Gideon. University Of Toronto. Hospital For Sick Children; Canadá. University of Toronto; Canadá  
dc.description.fil
Fil: Shannon, Michael W.. Children's Hospital Boston; Estados Unidos  
dc.description.fil
Fil: Garcia Bournissen, Facundo. University of Toronto; Canadá. University Of Toronto. Hospital For Sick Children; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Pediatrics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://publications.aap.org/pediatrics/article-abstract/128/4/723/30701/Recurrence-and-Outcomes-of-Stevens-Johnson?redirectedFrom=fulltext  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1542/peds.2010-3322