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dc.contributor.author
Sersa, Gregor
dc.contributor.author
Teissie, Justin
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Cemazar, Maja
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Signori, Emanuela
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Kamensek, Urska
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Marshall, Guillermo Ricardo
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Miklavcic, Damijan
dc.date.available
2017-06-30T19:54:32Z
dc.date.issued
2015-10
dc.identifier.citation
Sersa, Gregor; Teissie, Justin; Cemazar, Maja; Signori, Emanuela; Kamensek, Urska; et al.; Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer; Springer; Cancer Immunology Immunotherapy; 64; 10; 10-2015; 1315-1327
dc.identifier.issn
0340-7004
dc.identifier.uri
http://hdl.handle.net/11336/19319
dc.description.abstract
Electroporation is a platform technology for drug and gene delivery. When applied to cell in vitro or tissues in vivo, it leads to an increase in membrane permeability for molecules which otherwise cannot enter the cell (e.g., siRNA, plasmid DNA, and some chemotherapeutic drugs). The therapeutic effectiveness of delivered chemotherapeutics or nucleic acids depends greatly on their successful and efficient delivery to the target tissue. Therefore, the understanding of different principles of drug and gene delivery is necessary and needs to be taken into account according to the specificity of their delivery to tumors and/or normal tissues. Based on the current knowledge, electrochemotherapy (a combination of drug and electric pulses) is used for tumor treatment and has shown great potential. Its local effectiveness is up to 80 % of local tumor control, however, without noticeable effect on metastases. In an attempt to increase systemic antitumor effectiveness of electrochemotherapy, electrotransfer of genes with immunomodulatory effect (immunogene electrotransfer) could be used as adjuvant treatment. Since electrochemotherapy can induce immunogenic cell death, adjuvant immunogene electrotransfer to peritumoral tissue could lead to locoregional effect as well as the abscopal effect on distant untreated metastases. Therefore, we propose a combination of electrochemotherapy with peritumoral IL-12 electrotransfer, as a proof of principle, using electrochemotherapy boosted with immunogene electrotransfer as in situ vaccination for successful tumor treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Electroporation
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Electrochemotherapy
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Gene Electrotransfer
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Vaccination
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Abscopal Effect
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Pivac 14
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Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-30T14:38:01Z
dc.identifier.eissn
1432-0851
dc.journal.volume
64
dc.journal.number
10
dc.journal.pagination
1315-1327
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Sersa, Gregor. Institute of Oncology Ljubljana; Eslovenia
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Fil: Teissie, Justin. Centre National de la Recherche Scientifique; Francia
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Fil: Cemazar, Maja. Institute of Oncology Ljubljana; Eslovenia. University of Primorska; Eslovenia
dc.description.fil
Fil: Signori, Emanuela. Istituto di Farmacologia Traslazionale ; Italia
dc.description.fil
Fil: Kamensek, Urska. Institute of Oncology Ljubljana; Eslovenia
dc.description.fil
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.description.fil
Fil: Miklavcic, Damijan. University of Ljubljana; Eslovenia
dc.journal.title
Cancer Immunology Immunotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00262-015-1724-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00262-015-1724-2
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