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dc.contributor.author
Postemsky, Pablo Daniel
dc.contributor.author
Palermo, Ana María
dc.contributor.author
Curvetto, Nestor Raul
dc.date.available
2017-06-30T17:51:33Z
dc.date.issued
2011-12
dc.identifier.citation
Postemsky, Pablo Daniel; Palermo, Ana María; Curvetto, Nestor Raul; Protective Effects of New Medicinal Mushroom Grifola gargal Singer (Higher Basidiomycetes), on Induced DNA Damage in Somatic cells of Drosophila melanogaster; Begell House Inc; International Journal Of Medicinal Mushrooms; 13; 6; 12-2011; 583-594
dc.identifier.issn
1521-9437
dc.identifier.uri
http://hdl.handle.net/11336/19279
dc.description.abstract
Grifola gargal is an edible mushroom with attributed antioxidant properties. Different sources of G. gargal materials, i.e., fruit bodies and mycelia grown in liquid or solid media, were used to study its potential protective capacity when somatic mutation and recombination is induced in Drosophila melanogaster using DMBA (7-12-dimethyl-benz(α)anthracene) as promutagen. Heterozygote larvae (white/white+) were grown in media with different concentrations of DMBA. Grifola gargal fruit bodies (GgFB) or mycelia from liquid culture (GgLC) or from solid culture (GgWG), i.e., biotransformed wheat kernel flour, were added to the culture media in combined treatments with DMBA. Water, DMBA solvent, or wheat flour (WF) plus DMBA solvent were used as negative controls. Larval mortality increased from 9% to 11% in negative controls to 31% to 36% in DMBA treatments. The addition of GgFB, GgLC, or GgWG materials produced a protective effect on 25 μmol/vial DMBA-induced mortality. Mutations observed in SMART, as light spots per 100 eyes (LS/100 eyes), increased with increasing doses of DMBA; this was also true when considering the mutation incidence expressed as percentage of eyes exhibiting light spots (% eyes with LS). Interestingly, mycelia from GgFB, GgLC, or GgWG, in the presence of 25 μmol/vial DMBA, showed lower values in SMART of both the total LS/100 eyes and the percentage of eyes with LS. Thus, Grifola gargal materials were not only nontoxic, but in combination with 25 μmol/vial DMBA lowered the mortality induced by the promutagen and showed antimutagenic effects. Protective effects of G. gargal against DMBA are discussed in terms of the onset of desmutagenic and/or bioantimutagenic mechanisms of detoxification in the host organism, probably due to some bioactive compounds known to occur in higher mushrooms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Begell House Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Somatic Mutation And Recombination Test
dc.subject
Gifola Gargal
dc.subject
Wild-Forest Edible Mushrooms
dc.subject.classification
Micología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Micología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Protective Effects of New Medicinal Mushroom Grifola gargal Singer (Higher Basidiomycetes), on Induced DNA Damage in Somatic cells of Drosophila melanogaster
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-02T18:58:56Z
dc.journal.volume
13
dc.journal.number
6
dc.journal.pagination
583-594
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Postemsky, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina
dc.description.fil
Fil: Palermo, Ana María. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas Para la Defensa; Argentina
dc.description.fil
Fil: Curvetto, Nestor Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina
dc.journal.title
International Journal Of Medicinal Mushrooms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.dl.begellhouse.com/journals/708ae68d64b17c52,7b5e519241ca8193,311fb28f35fc39b4.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1615/IntJMedMushr.v13.i6.100
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