Artículo
Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
Honorato, Sara B.; Farfan, Silvia Nora; Viana, Arnaldo; Filho, Josué M.; Camarão, Gisela C.; Fechine, Francisco V.; Moraes, Maria E. A.; Moraes, Manoel O.; Ferro Seoane, Maribel; Dabbene, Viviana; Cuffini, Silvia Lucia
; Ayala, Alejandro Pedro
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
02/2012
Editorial:
Sociedade Brasileira de Química
Revista:
Journal of the Brazilian Chemical Society
ISSN:
0103-5053
e-ISSN:
1678-4790
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets. © 2012 Sociedade Brasileira de Química.
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Honorato, Sara B.; Farfan, Silvia Nora; Viana, Arnaldo; Filho, Josué M.; Camarão, Gisela C.; et al.; Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests; Sociedade Brasileira de Química; Journal of the Brazilian Chemical Society; 23; 2; 2-2012; 1-8
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