Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests

Honorato, Sara B.; Farfan, Silvia Nora; Viana, Arnaldo; Filho, Josué M.; Camarão, Gisela C.; Fechine, Francisco V.; Moraes, Maria E. A.; Moraes, Manoel O.; Ferro Seoane, Maribel; Dabbene, Viviana; Cuffini, Silvia Lucia; Ayala, Alejandro Pedro

doi:https://doi.org/10.1590/S0103-50532012000200005

Artículo

Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests

Honorato, Sara B.; Farfan, Silvia Nora; Viana, Arnaldo; Filho, Josué M.; Camarão, Gisela C.; Fechine, Francisco V.; Moraes, Maria E. A.; Moraes, Manoel O.; Ferro Seoane, Maribel; Dabbene, Viviana; Cuffini, Silvia Lucia Icon

; Ayala, Alejandro Pedro

Fecha de publicación: 02/2012

Editorial: Sociedade Brasileira de Química

Revista: Journal of the Brazilian Chemical Society

ISSN: 0103-5053

e-ISSN: 1678-4790

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets. © 2012 Sociedade Brasileira de Química.

Palabras clave: MEBENDAZOLE , POLYMORPHISM , RAMAN SPECTROSCOPY , SOLUBILITY , X-RAY POWDER DIFFRACTION

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/192720

URL: https://www.scielo.br/j/jbchs/a/9w7ztkRhJjzHYMcxrRJF3dc/abstract/?lang=en

DOI: https://doi.org/10.1590/S0103-50532012000200005

Colecciones

Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA

Citación

Honorato, Sara B.; Farfan, Silvia Nora; Viana, Arnaldo; Filho, Josué M.; Camarão, Gisela C.; et al.; Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests; Sociedade Brasileira de Química; Journal of the Brazilian Chemical Society; 23; 2; 2-2012; 1-8

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