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Artículo

Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study

Dambolena, Jose SebastianIcon ; Zunino, María PaulaIcon ; Herrera, Jimena MaríaIcon ; Pizzolitto, Romina PaolaIcon ; Areco, Vanessa AndreaIcon ; Zygadlo, Julio AlbertoIcon
Fecha de publicación: 21/08/2016
Editorial: Hindawi Publishing Corporation
Revista: Psyche
ISSN: 1415-1138
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Many insects affect food production and human health, and in an attempt to control these insects the use of synthetic insecticideshas become widespread. However, this has resulted in the development of resistance in these organisms, human diseases,contamination of food, and pollution of the environment. Plants natural products and essential oil components such as terpenesand phenylpropenes have been shown to have a significant potential for insect control. However, the molecular properties relatedto their insecticidal activity are not well understood. The purpose of this review is to provide an overview of the toxicity ofterpene compounds against three insects of importance to human health: lice, cockroaches, and Triatominae bugs and to evaluatewhich molecular descriptors are important in the bioactivity of terpenes. For the insects studied, quantitative structure-activityrelationship (QSAR) studies were performed in order to predict the insecticidal activity of terpene compounds. The obtainedQSAR models indicated that the activity of these compounds depends on their ability to reach the targets and to interact withthem.The QSAR analysis can be used to predict the bioactivities of other structurally related molecules. Our findings may providean important contribution in the search for new compounds with insecticidal activity.
Palabras clave: Qsar , Terpenes , Phenylpropenes , Human Health Insects
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/19269
URL: https://www.hindawi.com/journals/psyche/2016/4595823/
DOI: http://dx.doi.org/10.1155/2016/4595823
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Citación
Dambolena, Jose Sebastian; Zunino, María Paula; Herrera, Jimena María; Pizzolitto, Romina Paola; Areco, Vanessa Andrea; et al.; Terpenes: Natural Products for Controlling Insects of Importance to Human Health—A Structure-Activity Relationship Study; Hindawi Publishing Corporation; Psyche; 2016; 21-8-2016; 1-18
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