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dc.contributor.author
Laseca, Nora
dc.contributor.author
Molina, Antonio
dc.contributor.author
Ramón, Manuel
dc.contributor.author
Valera, Mercedes
dc.contributor.author
Azcona, Florencia
dc.contributor.author
Encina, Ana
dc.contributor.author
Demyda-peyrás, Sebastian
dc.date.available
2023-03-31T11:04:14Z
dc.date.issued
2022-02
dc.identifier.citation
Laseca, Nora; Molina, Antonio; Ramón, Manuel; Valera, Mercedes; Azcona, Florencia; et al.; Fine-Scale Analysis of Runs of Homozygosity Islands Affecting Fertility in Mares; Frontiers Media; Frontiers in Veterinary Science; 9; 2-2022; 1-9
dc.identifier.issn
2297-1769
dc.identifier.uri
http://hdl.handle.net/11336/192270
dc.description.abstract
The loss of genetic variability in livestock populations bred under strict selection processes is a growing concern, as it may lead to increased inbreeding values and lower fertility, as a consequence of the “inbreeding depression” effect. This is particularly important in horses, where inbreeding levels tend to rise as individuals become more and more closely related. In this study, we evaluated the effect of increased inbreeding levels on mare fertility by combining an SNP-based genomic approach using runs of homozygosity and the estimation of genetic breeding values for reproductive traits in a large population of Pura Raza Española mares. Our results showed a negative correlation between whole-genome homozygosity and fertility estimated breeding values (EBVs) at the genome level (ρ = −0.144). However, the analysis at chromosome level revealed a wide variability, with some chromosomes showing higher correlations than others. Interestingly, the correlation was stronger (−0.241) when we repeated the analysis in a reduced dataset including the 10% most and least fertile individuals, where the latter showed an increase in average inbreeding values (FROH) of around 30%. We also found 41 genomic regions (ROHi, runs of homozygosity islands) where homozygosity increased 100-fold, 13 of which were significantly associated with fertility after cross-validation. These regions encompassed 17 candidate genes previously related to oocyte and embryo development in several species. Overall, we demonstrated the relationship between increased homozygosis at the genomic level and fertility in mares. Our findings may help to deal with the occurrence of inbreeding depression, as well as further our understanding of the mechanisms underlying fertility in mares.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FERTILITY
dc.subject
GENOMICS
dc.subject
INBREEDING
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MARES
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REPRODUCTIVE EFFICIENCY
dc.subject
ROHI
dc.subject
RUNS OF HOMOZYGOSITY
dc.subject
SNP
dc.subject.classification
Tecnología GM, clonación de ganado, selección asistida, diagnósticos, tecnología de producción de biomasa, etc.
dc.subject.classification
Biotecnología Agropecuaria
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Fine-Scale Analysis of Runs of Homozygosity Islands Affecting Fertility in Mares
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-29T17:15:41Z
dc.journal.volume
9
dc.journal.pagination
1-9
dc.journal.pais
Suiza
dc.description.fil
Fil: Laseca, Nora. Universidad de Córdoba; España
dc.description.fil
Fil: Molina, Antonio. Universidad de Córdoba; España
dc.description.fil
Fil: Ramón, Manuel. Instituto Regional de Investigación y Desarrollo Agroalimentario y Forestal Castilla La Mancha; España
dc.description.fil
Fil: Valera, Mercedes. Universidad de Sevilla; España
dc.description.fil
Fil: Azcona, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil
Fil: Encina, Ana. Universidad de Sevilla; España
dc.description.fil
Fil: Demyda-peyrás, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Frontiers in Veterinary Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fvets.2022.754028/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fvets.2022.754028
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