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dc.contributor.author
Blanco, Maria Gabriela  
dc.contributor.author
de Rosa, Maria Jose  
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Rayes, Diego Hernán  
dc.date.available
2023-03-31T02:11:26Z  
dc.date.issued
2019  
dc.identifier.citation
Serotonin (5-HT) and catecholamines (CA) antagonistic food-related behaviors in C. elegans; XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); Villa Carlos Paz; Argentina; 2019; 43-43  
dc.identifier.uri
http://hdl.handle.net/11336/192244  
dc.description.abstract
Despite the intermodulation between serotonergic and adrenergic signals is crucial throughout the animal kingdom, the molecular and cellular mechanisms underlying this interrelation are poorly understood. We here use C. elegans as a model to get insights into the neural circuits linking 5-TH and CA. When food-deprived worms encounter food, 5-HT is released to slow-down their locomotion and to stimulate pharyngeal pumping.In contrast, exogenous Tyramine (TA) and Octopamine (OA), invertebrate counterparts for adrenaline and noradrenaline, stimulate locomotion and decreases pharyngeal pumping. We found that tdc-1 mutants (unable to synthesize TA and OA) are hypersensitive to 5-HT-mediated paralysis, suggesting that TA and OA acts antagonistically to 5-HT. We also identify the TA (TYRA-3) and OA (SER-3 and SER-6) receptors involved in this antagonism. Moreover, our calcium imaging recordings showed that the peak of activity of serotoninergic neurons upon encountering food is significantly higher in tdc-1 null mutant background. Taken together these results suggest that TA and OA counteract serotoninergic signaling by driving opposing behaviors and by inhibiting 5-HT release. Our final aim is to decipher the neural circuit and the molecules involved in the reciprocal modulation between CA and 5-HT in C. elegans. Given the conservation in molecular components of these pathways, our studies are likely significant to understand this interrelation in other animals.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Sociedad Argentina de Investigación en Neurociencias  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BIOGENIC AMINES  
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ANTAGONISM  
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NEURONAL ACTIVITY  
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FOOD  
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Bioquímica y Biología Molecular  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Serotonin (5-HT) and catecholamines (CA) antagonistic food-related behaviors in C. elegans  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/conferenceObject  
dc.type
info:ar-repo/semantics/documento de conferencia  
dc.date.updated
2023-02-16T10:12:04Z  
dc.journal.pagination
43-43  
dc.journal.pais
Argentina  
dc.journal.ciudad
Bs As  
dc.description.fil
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina  
dc.description.fil
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina  
dc.description.fil
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/  
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Autor  
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Autor  
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Autor  
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Nacional  
dc.type.subtype
Congreso  
dc.description.nombreEvento
XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN)  
dc.date.evento
2019-10-03  
dc.description.ciudadEvento
Villa Carlos Paz  
dc.description.paisEvento
Argentina  
dc.type.publicacion
Book  
dc.description.institucionOrganizadora
Sociedad Argentina de Investigación en Neurociencias  
dc.source.libro
SAN Sociedad Argentina de Investigación en Neurociencias  
dc.date.eventoHasta
2019-01-05  
dc.type
Congreso