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dc.contributor.author
Jiménez Ortega, Vanesa
dc.contributor.author
Fernández Mateos, María P.
dc.contributor.author
Barquilla, Pilar Cano
dc.contributor.author
Cardinali, Daniel Pedro
dc.contributor.author
Esquifino, Ana I.
dc.date.available
2023-03-29T16:09:14Z
dc.date.issued
2011-03
dc.identifier.citation
Jiménez Ortega, Vanesa; Fernández Mateos, María P.; Barquilla, Pilar Cano; Cardinali, Daniel Pedro; Esquifino, Ana I.; Continuous versus discontinuous drinking of an ethanol liquid diet in peripubertal rats: Effect on 24-h variation of lymph node and splenic mitogenic responses and lymphocyte subset populations; Elsevier Science Inc.; Alcohol; 45; 2; 3-2011; 183-192
dc.identifier.issn
0741-8329
dc.identifier.uri
http://hdl.handle.net/11336/192061
dc.description.abstract
Excessive alcohol consumption continues to be a major public health problem, particularly in the adolescent and young adult populations. Generally, such a behavior tends to be confined to the weekends, to attain frequently binge drinking. This study in peripubertal male rats compares the effect of the discontinuous feeding of a liquid diet containing a moderate amount of ethanol (6.2% wt/vol) to that of continuous ethanol administration or a control diet, taking as end points the 24-h variations of plasma prolactin levels and mitogenic responses and lymphocyte subset populations in submaxillary lymph nodes and spleen. Animals received the ethanol liquid diet starting on day 35 of life, the diet being similar to that given to controls except for that maltose was isocalorically replaced by ethanol. Ethanol provided 36% of the total caloric content. Every week, the discontinuous ethanol group received the ethanol diet for 3 days and the control liquid diet for the remaining 4 days. After 4 weeks, rats were killed at six time intervals, beginning at 0900h. A significant decrease of splenic cells' response to concanavalin A, and of lymph node and splenic cells' response to lipopolysaccharide was found in rats under the discontinuous ethanol regime, when compared with control- or ethanol-chronic rats. Under discontinuous ethanol feeding, mean values of lymph node and splenic CD8+ and CD4+-CD8+cells decreased, whereas those of lymph node and splenic T cells, and splenic B cells, augmented. In rats chronically fed with ethanol, splenic mean levels of CD8+ and CD4+-CD8+cells augmented. Both modalities of ethanol administration disrupted the 24h variation in immune function seen in controls. Mean plasma prolactin levels increased by 3.6-fold and 8.5-fold in rats chronically or discontinuously fed with alcohol, respectively. The immune parameters examined in an additional group of rats fed regular chow and water ad libitum did not differ significantly from control liquid diet. The results support the view that the discontinuous drinking of a moderate amount of ethanol can be more harmful for the immune system than a continuous ethanol intake, presumably by inducing a greater stress as indicated by the augmented plasma prolactin levels observed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BINGE DRINKING
dc.subject
MITOGENIC RESPONSES
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LYMPHOCYTE SUBSETS
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CIRCADIAN RHYTHMS
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PROLACTIN
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STRESS
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Continuous versus discontinuous drinking of an ethanol liquid diet in peripubertal rats: Effect on 24-h variation of lymph node and splenic mitogenic responses and lymphocyte subset populations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-28T14:20:07Z
dc.journal.volume
45
dc.journal.number
2
dc.journal.pagination
183-192
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Fernández Mateos, María P.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Barquilla, Pilar Cano. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
dc.journal.title
Alcohol
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0741832910001175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.alcohol.2010.08.008
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