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dc.contributor.author
Gil, Félix
dc.contributor.author
Pérez Filgueira, Daniel Mariano
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dc.contributor.author
Barderas, María G.
dc.contributor.author
Pastor Vargas, Carlos
dc.contributor.author
Alonso, Covadonga
dc.contributor.author
Vivanco, Fernando
dc.contributor.author
Escribano, José M.
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dc.date.available
2023-03-28T14:10:55Z
dc.date.issued
2011-01
dc.identifier.citation
Gil, Félix; Pérez Filgueira, Daniel Mariano; Barderas, María G.; Pastor Vargas, Carlos; Alonso, Covadonga; et al.; Targeting antigens to an invariant epitope of the MHC Class II DR molecule potentiates the immune response to subunit vaccines; Elsevier Science; Virus Research; 155; 1; 1-2011; 55-60
dc.identifier.issn
0168-1702
dc.identifier.uri
http://hdl.handle.net/11336/191854
dc.description.abstract
Recombinant subunit and peptidic vaccines in general present a reduced immunogenicity in vaccinated individuals with respect to the whole pathogen from which they derived. The generation of strong immune responses to these vaccines requires the use of potent adjuvants, high antigen doses and repetitive vaccinations. In this report, we document the enhanced antibody response obtained against two recombinant subunit vaccines by means of targeting to antigen-presenting cells by a recombinant single chain antibody. This antibody, named APCH1, recognizes an epitope of MHC Class II DR molecule preserved in different animal species, including humans. We showed that vaccinal antigens translationally fused to APCH1 antibody and produced by recombinant baculoviruses in insect larvae (Trichoplusia ni), elicited an increased antibody response in comparison with the same antigens alone or fused to a carrier molecule. These results suggest that targeting of antigens to this invariant MHC Class II epitope has immunopotentiating effects that could circumvent the reduced potency of peptidic or subunit vaccines, opening the possibility of widespread application of APCH1 as a new adjuvant antibody of general use.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADJUVANT
dc.subject
ANTIGEN TARGETING
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CANINE PARVOVIRUS
dc.subject
RHDV
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SUBUNIT VACCINE
dc.subject.classification
Otras Biotecnología Agropecuaria
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dc.subject.classification
Biotecnología Agropecuaria
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Targeting antigens to an invariant epitope of the MHC Class II DR molecule potentiates the immune response to subunit vaccines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-23T12:35:15Z
dc.journal.volume
155
dc.journal.number
1
dc.journal.pagination
55-60
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gil, Félix. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Pérez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria; Argentina
dc.description.fil
Fil: Barderas, María G.. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Pastor Vargas, Carlos. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Alonso, Covadonga. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Vivanco, Fernando. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Escribano, José M.. Consejo Superior de Investigaciones Científicas; España
dc.journal.title
Virus Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168170210003175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.virusres.2010.08.022
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