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dc.contributor.author
Rodriguez Rodrigues, Nahuel Emiliano
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Duran, Adriana
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Bouzas, Maria Belen
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Zapiola, Ines
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Vila, Marcelo
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Indyk, Debbie
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Bissio, Emiliano
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Salomon, Horacio Eduardo
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Dilernia, Dario Alberto
dc.date.available
2015-09-03T16:08:13Z
dc.date.issued
2013-10-03
dc.identifier.citation
Rodriguez Rodrigues, Nahuel Emiliano; Duran, Adriana; Bouzas, Maria Belen; Zapiola, Ines; Vila, Marcelo; et al.; Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina; International AIDS Society; Journal of the International AIDS Society; 16; 3-10-2013; 1-6
dc.identifier.issn
1758-2652
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http://hdl.handle.net/11336/1917
dc.description.abstract
Objective: Our objective was to estimate primary resistance in an urban setting in a developing country characterized by high antiretroviral (ARV) coverage over the diagnosed population and also by an important proportion of undiagnosed individuals, in order to determine whether any change in primary resistance occurred in the past five years. Design: We carried out a multi-site resistance surveillance study according to WHO HIV resistance guidelines, using a weighted sampling technique based on annual HIV case reports per site. Methods: Blood samples were collected from 197 drug-naive HIV-1-infected individuals diagnosed between March 2010 and August 2011 at 20 HIV voluntary counselling and testing centres in Buenos Aires. Clinical records of enrolled patients at the time of diagnosis were compiled. Viral load and CD4 counts were performed on all samples. The pol gene was sequenced and the resistance profile determined. Phylogenetic analysis was performed by neighbour-joining (NJ) trees and bootscanning analysis. Results: We found that 12 (7.9%) of the 152 successfully sequenced samples harboured primary resistance mutations, of which K103N and G190A were the most prevalent. Non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance mutations were largely the most prevalent (5.9%), accounting for 75% of all primary resistance and exhibiting a significant increase (p =0.0072) in prevalence during the past 10 years as compared to our previous study performed in 1997-2000 and in 2003-2005. Nucleoside reverse transcriptase inhibitor (NRTI) and protease inhibitor primary resistance were low and similar to the one previously reported. Conclusions: Levels of primary NNRTI resistance in Buenos Aires appear to be increasing in the context of a sustained ARV coverage and a high proportion of undiagnosed HIV-positive individuals. © 2013 Rodriguez-Rodrigues N et al; licensee International AIDS Society.
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application/pdf
dc.language.iso
eng
dc.publisher
International AIDS Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIV
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NEWLY DIAGNOSED
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NNRTI
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PRIMARY DRUG RESISTANCE
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TREND
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Ciencias Biomédicas Sociales
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
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info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
16
dc.journal.pagination
1-6
dc.journal.pais
Suiza
dc.journal.ciudad
Ginebra
dc.description.fil
Fil: Rodriguez Rodrigues, Nahuel Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
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Fil: Duran, Adriana. Ministerio de Salud de la Nación; Argentina
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Fil: Bouzas, Maria Belen. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
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Fil: Zapiola, Ines. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
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Fil: Vila, Marcelo. Organizacion Mundial de la Salud; Argentina
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Fil: Indyk, Debbie. Icahn School of Medicine at Mount Sinai; Estados Unidos
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Fil: Bissio, Emiliano. Ministerio de Salud de la Nación; Argentina
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Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
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Fil: Dilernia, Dario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.journal.title
Journal of the International AIDS Society
dc.relation.isreferencedin
info:eu-repo/semantics/reference/url/info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/24093951
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7448/IAS.16.1.18519
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info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790908/pdf/JIAS-16-18519.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jiasociety.org/index.php/jias/article/view/18519/3212
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