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dc.contributor.author
Blanco, Rancés  
dc.contributor.author
Rengifo, Enrique  
dc.contributor.author
Cedeño, Mercedes  
dc.contributor.author
Rengifo, Charles E.  
dc.contributor.author
Alonso, Daniel Fernando  
dc.contributor.author
Carr, Adriana  
dc.date.available
2023-03-23T18:00:33Z  
dc.date.issued
2011-12  
dc.identifier.citation
Blanco, Rancés; Rengifo, Enrique; Cedeño, Mercedes; Rengifo, Charles E.; Alonso, Daniel Fernando; et al.; Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Epithelial Malignant Tumors from Digestive System; Hindawi Publishing Corporation; International Scholarly Research Network; 2011; 12-2011; 1-8  
dc.identifier.issn
2090-4401  
dc.identifier.uri
http://hdl.handle.net/11336/191640  
dc.description.abstract
The limited expression of N-Glycolyl GM3 (NeuGcGM3) ganglioside in human normal tissues, as well as its presence in melanoma and breast carcinoma using 14F7 Mab (anti-NeuGcGM3), has been previously reported. In this work we evaluated for the first time the 14F7 Mab immunorecognition in some digestive system tumors. Immunohistochemical assays were made with 14F7, followed by anti-mouse biotinylated antibody and ABC/HRP system in normal and pathological human tissues were made. No immunoreaction was evidenced in normal tissues. The reactivity of 14F7 was detected in all adenocarcinomas of the stomach (12/12), colon (12/12), and pancreas (11/11). A finely granular immunorecognition in esophageal tumors (5/15), epidermoid carcinoma of the rectum (5/7), and basaloid carcinoma (4/5) of the latter as well as in hepatocellular carcinoma (13/14) was also observed. Our results are in agreement with the assumption that NeuGcGM3 ganglioside may be considered as target for passive and active immunotherapy in digestive system malignancies expressing this molecule.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Hindawi Publishing Corporation  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Gastrointestinal tumors  
dc.subject
Gangliosides  
dc.subject
Immunohistochimistry  
dc.subject
Monoclonal antibody  
dc.subject.classification
Patología  
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Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Epithelial Malignant Tumors from Digestive System  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-03-23T12:38:47Z  
dc.journal.volume
2011  
dc.journal.pagination
1-8  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Blanco, Rancés. No especifíca;  
dc.description.fil
Fil: Rengifo, Enrique. No especifíca;  
dc.description.fil
Fil: Cedeño, Mercedes. No especifíca;  
dc.description.fil
Fil: Rengifo, Charles E.. Manuel Fajardo General Hospital; Cuba  
dc.description.fil
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Carr, Adriana. No especifíca;  
dc.journal.title
International Scholarly Research Network  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/isrn/gastroenterology/2011/645641/  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5402/2011/645641