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dc.contributor.author
Ferrari, Carina Cintia  
dc.contributor.author
Tarelli, Rodolfo  
dc.date.available
2023-03-23T15:49:25Z  
dc.date.issued
2011-01  
dc.identifier.citation
Ferrari, Carina Cintia; Tarelli, Rodolfo; Parkinson's disease and systemic inflammation; Hindawi Publishing Corporation; Parkinson's Disease; 2011; 436; 1-2011; 1-9  
dc.identifier.issn
2042-0080  
dc.identifier.uri
http://hdl.handle.net/11336/191623  
dc.description.abstract
Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain. In Parkinson's disease (PD), inflammation was mainly associated with microglia activation that can underlie the neurodegeneration of neurons in the substantia nigra (SN). Peripheral inflammation can transform the primed microglia into an active state, which can trigger stronger responses dealing with neurodegenerative processes. Numerous evidences show that systemic inflammatory processes exacerbate ongoing neurodegeneration in PD patient and animal models. Anti-inflammatory treatment in PD patients exerts a neuroprotective effect. In the present paper, we analyse the effect of peripheral infections in the etiology and progression in PD patients and animal models, suggesting that these peripheral immune challenges can exacerbate the symptoms in the disease.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Hindawi Publishing Corporation  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Parkinson`s  
dc.subject
peripheral inflammation  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Parkinson's disease and systemic inflammation  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-03-23T12:31:54Z  
dc.journal.volume
2011  
dc.journal.number
436  
dc.journal.pagination
1-9  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Ferrari, Carina Cintia. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Tarelli, Rodolfo. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Parkinson's Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4061/2011/436813