Mostrar el registro sencillo del ítem
dc.contributor.author
Jiang, Zhihong
dc.contributor.author
Belforte, Juan Emilio
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Lu, Yuan
dc.contributor.author
Yabe, Yoko
dc.contributor.author
Pickel, James
dc.contributor.author
Smith, Carolyn Beebe
dc.contributor.author
Je, Hyun Soo
dc.contributor.author
Lu, Bai
dc.contributor.author
Nakazawa, Kazu
dc.date.available
2023-03-22T11:32:33Z
dc.date.issued
2010-02
dc.identifier.citation
Jiang, Zhihong; Belforte, Juan Emilio; Lu, Yuan; Yabe, Yoko; Pickel, James; et al.; eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation; Society for Neuroscience; Journal of Neuroscience; 30; 7; 2-2010; 2582-2594
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/191323
dc.description.abstract
Protein synthesis inhibitor antibiotics are widely used to produce amnesia, and have been recognized to inhibit general or global mRNA translation in the basic translational machinery. For instance, anisomycin interferes with protein synthesis by inhibiting peptidyl transferase or the 80S ribosomal function. Therefore, de novo general or global protein synthesis has been thought to be necessary for long-term memory formation. However, it is unclear which mode of translation - gene-specific translation or general/global translation - is actually crucial for the memory consolidation process in mammalian brains. Here, we generated a conditional transgenic mouse strain in which double-strand RNA-dependent protein kinase (PKR)-mediated phosphorylation of eIF2α, a key translation initiation protein, was specifically increased in hippocampal CA1 pyramidal cells by the chemical inducer AP20187. Administration of AP20187 significantly increased activating transcription factor 4 (ATF4) translation and concomitantly suppressed CREB-dependent pathways in CA1 cells; this led to impaired hippocampal late-phase LTP and memory consolidation, with no obvious reduction in general translation. Conversely, inhibition of general translation by low-dose anisomycin failed to block hippocampal-dependent memory consolidation. Together, these results indicated that CA1-restricted genetic manipulation of particular mRNA translations is sufficient to impair the consolidation and that consolidation of memories in CA1 pyramidal cells through eIF2α dephosphorylation depends more on transcription/ translation of particular genes than on overall levels of general translation. The present study sheds light on the critical importance of gene-specific translations for hippocampal memory consolidation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
memoria
dc.subject
sintesis proteica
dc.subject.classification
Otras Ciencias Médicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Otras Ciencias Médicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-20T14:58:48Z
dc.journal.volume
30
dc.journal.number
7
dc.journal.pagination
2582-2594
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Jiang, Zhihong. No especifíca;
dc.description.fil
Fil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lu, Yuan. No especifíca;
dc.description.fil
Fil: Yabe, Yoko. No especifíca;
dc.description.fil
Fil: Pickel, James. No especifíca;
dc.description.fil
Fil: Smith, Carolyn Beebe. No especifíca;
dc.description.fil
Fil: Je, Hyun Soo. National Instituto of Child Health & Human Development; Estados Unidos
dc.description.fil
Fil: Lu, Bai. National Instituto of Child Health & Human Development; Estados Unidos
dc.description.fil
Fil: Nakazawa, Kazu. No especifíca;
dc.journal.title
Journal of Neuroscience
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jneurosci.org/content/30/7/2582.short
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.3971-09.2010
Archivos asociados