Artículo
Inhibition of connexin 43 in cardiac muscle during intense physical exercise
Tiscornia, Gisela Carla
; Moretta, Rosalia Ester
; Argenziano, Mariana Alejandra
; Amorena, Carlos Ernesto
; Garcia Gras, Eduardo Andres
Fecha de publicación:
08/2012
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Scandinavian Journal Of Medicine & Science In Sports
ISSN:
0905-7188
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Endurance training is accompanied by important adaptations in both cardiovascular and autonomic nervous systems. Previous works have shown that the main component of gap junctions in the ventricular myocardium (connexin 43 (Cx43) can be regulated by adrenergic stimulus. On the other hand, training raises vagal and decreases sympathetic tone, while augmenting myocardial sensitivity to sympathetic stimulation during exercise. We therefore evaluated the regulation of Cx43 expression by sympathetic tone during exercise in trained and sedentary mice. Training induced an increase in the protein level of Cx43 by 45-70% under resting conditions. The expression of Cx43 was inhibited in trained but not in untrained mice in response to a 60min exercise bout. Normal basal expression was restored after 60min of resting. Cx43 reached a minimum that was not different from basal expression in untrained mice. In accordance, electrocardiography and action potential analysis did not reveal major electrophysiological implications for the drop in Cx43 abundance in trained-exercise mice. We prevented Cx43 inhibition using propranolol, and observed increased basal mRNA levels of β-adrenergic receptors without significant changes in the ratio β1 to β2. In conclusion, we showed that Cx43 expression is transiently inhibited by β-adrenergic stimulus in trained mice during acute exercise.
Palabras clave:
ENDURANCE TRAINING
,
GAP JUNCTION
,
SWIMMING
,
SYMPATHETIC
Archivos asociados
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Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Tiscornia, Gisela Carla; Moretta, Rosalia Ester; Argenziano, Mariana Alejandra; Amorena, Carlos Ernesto; Garcia Gras, Eduardo Andres; Inhibition of connexin 43 in cardiac muscle during intense physical exercise; Wiley Blackwell Publishing, Inc; Scandinavian Journal Of Medicine & Science In Sports; 24; 2; 8-2012; 336-344
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