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Artículo

Cutaneous Melanoma: A Test Field for Immunotherapy and a Medical Challenge

Aris, MarianaIcon ; Barrio, Maria MarcelaIcon ; Mordoh, JoseIcon
Fecha de publicación: 08/2010
Editorial: Bentham Science Publishers
Revista: Current Cancer Therapy reviews
ISSN: 1573-3947
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Oncología

Resumen

Cutaneous melanoma (CM) is the fourth tumor in frequency, and that whose incidence increases faster. In half of the cases, CM arises from pre-existing nevi. CM is a highly heterogeneous tumor, whose degree of differentiation varies among different hosts, and such heterogeneity is probably based on the accumulation of mutations that determine transitions from normal melanocytic stem cells mutated benign melanocytic stem cells malignant melanocytic stem cells clonogenic melanocytic cells. These populations may express different antigens and would therefore trigger the proliferation of different T and B cell clones. Early diagnosis is the clue for the cure of CM; when visceral metastatic disease is established, the prognosis is somber. This is especially so since CM is quite resistant to chemotherapy, and some of the reasons for such resistance will be discussed here. However, CM has proved to be sensitive to immunological effectors, although the mechanism of such sensitivity is still being investigated. These effectors range from therapeutic vaccines, in vitro expanded cytotoxic lymphocytes, cytokines, and monoclonal antibodies. Finally, we will discuss new therapeutic approaches that include the combination of immune modulators and vaccines which are being assayed in light of recent tumor immunology research.
Palabras clave: MELANOMA DEVELOPMENT , CHEMOTHERAPY RESISTANCE , IMMUNOTHERAPY , CANCER VACCINES
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/190912
URL: https://www.eurekaselect.com/article/17040
DOI: http://dx.doi.org/10.2174/157339410791698232
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Aris, Mariana; Barrio, Maria Marcela; Mordoh, Jose; Cutaneous Melanoma: A Test Field for Immunotherapy and a Medical Challenge; Bentham Science Publishers; Current Cancer Therapy reviews; 6; 3; 8-2010; 229-242
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